Phenolic Glycosides from the Twigs of Salix glandulosa
- Authors
- Kim, Chung Sub; Kwon, Oh Wook; Kim, Sun Yeou; Choi, Sang Un; Kim, Jae Yoon; Han, Ji Young; Choi, Soo Im; Choi, Jong Gil; Kim, Ki Hyun; Lee, Kang Ro
- Issue Date
- Aug-2014
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.77, no.8, pp.1955 - 1961
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 77
- Number
- 8
- Start Page
- 1955
- End Page
- 1961
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12456
- DOI
- 10.1021/np500488v
- ISSN
- 0163-3864
- Abstract
- As a part of an ongoing search for bioactive constituents from Korean medicinal plants, the phytochemical investigations of the twigs of Salix glandulosa afforded 12 new phenolic glycosides (1-12) and a known analogue (13). The structures of 1-13 were characterized by a combination of NMR methods (H-1 and C-13 NMR, H-1-H-1 COSY, HMQC, and HMBC), chemical hydrolysis, and GC/MS. The absolute configuration of 13 [(1R,2S)-2-hydroxycyclohexyl-2'-O-trans-p-coumaroyl-beta-D-glucopyranoside] was determined for the first time. Compounds 1-3, 6, and 7 exhibited inhibitory effects on nitric oxide production in lipopolysaccharide-activated murine microglial cells (IC50 values in the range 6.6-20.5 mu M).
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Collections - 약학대학 > 약학과 > 1. Journal Articles
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