Clinical Availability of Component-Resolved Diagnosis Using Microarray Technology in Atopic Dermatitis
DC Field | Value | Language |
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dc.contributor.author | Choi, Joon-Seok | - |
dc.contributor.author | Roh, Joo-Young | - |
dc.contributor.author | Lee, Jong-Rok | - |
dc.date.available | 2020-02-28T16:46:18Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-08 | - |
dc.identifier.issn | 1013-9087 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12458 | - |
dc.description.abstract | Background: Various allergens play a role in the elicitation or exacerbation of eczematous skin lesions in atopic dermatitis (AD), and much research effort has been focused on improving diagnostic tests to identify causative allergens. Objective: The purpose of this study was to evaluate the diagnostic effectiveness of a newly introduced microarray-based specific immunoglobulin E detection assay, Immuno-CAP ISAC, for use in AD patients. Methods: The serum samples of 25 AD patients were tested by using ISAC and a multiple allergen simultaneous test-enzyme immunoassay (MAST-EIA). In addition, 10 of the 25 patients underwent skin prick testing (SPT). The positive reaction rates to allergens in each test and the agreements, sensitivities, and specificities of ISAC and MAST-EIA were evaluated versus the SPT results. Results: For ISAC versus SPT, the overall results were as follows: sensitivity, 90.0%; specificity, 98.2%; positive predictive value (PPV), 90.0%; and negative predictive value (NPV), 98.2%. The total agreement and K value for ISAC versus SPT were 96.9% and 0.882, respectively. For MAST-EIA versus SPT, the sensitivity was 80.0%, specificity 92.7%, PPV 66.7%, and NPV 96.2%. The total agreement and K value for MAST-EIA versus SPT were 90.8% and 0.672, respectively. The overall agreement between the ISAC and MAST-EIA results was 88%. Conclusion: The ISAC results in AD correlated well with the SPT results, and compared favorably to the MAST-EIA results. This study demonstrates the potential of ISAC as a convenient allergic diagnostic method in AD patients. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN DERMATOLOGICAL ASSOC | - |
dc.relation.isPartOf | ANNALS OF DERMATOLOGY | - |
dc.subject | LIPID-TRANSFER PROTEIN | - |
dc.subject | MOLECULAR DIAGNOSIS | - |
dc.subject | IGE MEASUREMENT | - |
dc.subject | ALLERGY | - |
dc.subject | TESTS | - |
dc.subject | FOOD | - |
dc.subject | TOOL | - |
dc.subject | IMMUNOTHERAPY | - |
dc.title | Clinical Availability of Component-Resolved Diagnosis Using Microarray Technology in Atopic Dermatitis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000341073000002 | - |
dc.identifier.doi | 10.5021/ad.2014.26.4.437 | - |
dc.identifier.bibliographicCitation | ANNALS OF DERMATOLOGY, v.26, no.4, pp.437 - 446 | - |
dc.identifier.kciid | ART001898846 | - |
dc.identifier.scopusid | 2-s2.0-84928032622 | - |
dc.citation.endPage | 446 | - |
dc.citation.startPage | 437 | - |
dc.citation.title | ANNALS OF DERMATOLOGY | - |
dc.citation.volume | 26 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Choi, Joon-Seok | - |
dc.contributor.affiliatedAuthor | Roh, Joo-Young | - |
dc.contributor.affiliatedAuthor | Lee, Jong-Rok | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Atopic dermatitis | - |
dc.subject.keywordAuthor | Microarray-based specific IgE detection assay | - |
dc.subject.keywordPlus | LIPID-TRANSFER PROTEIN | - |
dc.subject.keywordPlus | MOLECULAR DIAGNOSIS | - |
dc.subject.keywordPlus | IGE MEASUREMENT | - |
dc.subject.keywordPlus | ALLERGY | - |
dc.subject.keywordPlus | TESTS | - |
dc.subject.keywordPlus | FOOD | - |
dc.subject.keywordPlus | TOOL | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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