Leptin-promoted cilia assembly is critical for normal energy balance
- Authors
- Han, Yu Mi; Kang, Gil Myoung; Byun, Kyunghee; Ko, Hyuk Wan; Kim, Joon; Shin, Mi-Seon; Kim, Hyun-Kyong; Gil, So Young; Yu, Ji Hee; Lee, Bonghee; Kim, Min-Seon
- Issue Date
- May-2014
- Publisher
- AMER SOC CLINICAL INVESTIGATION INC
- Citation
- JOURNAL OF CLINICAL INVESTIGATION, v.124, no.5, pp.2193 - 2197
- Journal Title
- JOURNAL OF CLINICAL INVESTIGATION
- Volume
- 124
- Number
- 5
- Start Page
- 2193
- End Page
- 2197
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12652
- DOI
- 10.1172/JCI69395
- ISSN
- 0021-9738
- Abstract
- The majority of mammalian cells have nonmotile primary cilia on their surface that act as antenna-like sensory organelles. Genetic defects that result in ciliary dysfunction are associated with obesity in humans and rodents, which suggests that functional cilia are important for controlling energy balance. Here we demonstrated that neuronal cilia lengths were selectively reduced in hypothalami of obese mice with leptin deficiency and leptin resistance. Treatment of N1 hypothalamic neuron cells with leptin stimulated cilia assembly via inhibition of the tumor suppressors PTEN and glycogen synthase kinase 3 beta (GSK3 beta). Induction of short cilia in the hypothalamus of adult mice increased food intake and decreased energy expenditure, leading to a positive energy balance. Moreover, mice with short hypothalamic cilia exhibited attenuated anorectic responses to leptin, insulin, and glucose, which indicates that leptin-induced cilia assembly is essential for sensing these satiety signals by hypothalamic neurons. These data suggest that leptin governs the sensitivity of hypothalamic neurons to metabolic signals by controlling the length of the cell's antenna.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의예과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12652)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.