Non-HDL cholesterol is an independent risk factor for aspirin resistance in obese patients with type 2 diabetes
- Authors
- Kim, Jong Dai; Park, Cheol-Young; Ahn, Kue Jeong; Cho, Jae Hyoung; Choi, Kyung Mook; Kang, Jun Goo; Kim, Jae Hyeon; Lee, Ki Young; Lee, Byung Wan; Mok, Ji Oh; Moon, Min Kyong; Park, Joong Yeol; Park, Sung Woo
- Issue Date
- May-2014
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Aspirin resistance; Non-HDL cholesterol; Atherogenic dyslipidemia; Diabetes
- Citation
- ATHEROSCLEROSIS, v.234, no.1, pp.146 - 151
- Journal Title
- ATHEROSCLEROSIS
- Volume
- 234
- Number
- 1
- Start Page
- 146
- End Page
- 151
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12657
- DOI
- 10.1016/j.atherosclerosis.2014.01.015
- ISSN
- 0021-9150
- Abstract
- Objective: We evaluated the prevalence of aspirin resistance and predictive factors for aspirin resistance in Korean type 2 diabetes patients. Approach and results: A total of 1045 type 2 diabetes patients from 11 hospitals who were taking aspirin (100 mg/day for >= 2 weeks) and no other antiplatelet agents were studied to evaluate aspirin resistance. Aspirin resistance was measured in aspirin reaction units using VerifyNow (R). Aspirin resistance was defined as >= 550 aspirin reaction units. Aspirin resistance was detected in 102 of the 1045 subjects (prevalence 9.8%). Aspirin resistance was associated with total cholesterol (P = 0.013), LDL-cholesterol (P = 0.028), and non-HDL cholesterol (P = 0.008) concentrations in univariate analysis. In multivariate logistic regression analysis, only non-HDL cholesterol was associated with aspirin resistance in obese (BMI > 25 kg/m(2)) type 2 diabetes patients (adjusted odds ratio 3.55, 95% CI: 1.25-10.05, P = 0.017). Conclusions: The prevalence of aspirin resistance in Korean type 2 diabetes patients is 9.8%. Non-HDL cholesterol is an independent risk factor for aspirin resistance, especially in obese type 2 diabetes patients. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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