Survey of perinatal hepatitis B virus transmission after Korean National Prevention Program in a tertiary hospital
- Authors
- Kim, Jae Hoon; Kim, Ju Seung; Lee, Jong Joon; Kim, Jung Ho; Kim, Suk Young; Jung, Young Kul; Kwon, Oh Sang; Kim, Yun Soo; Choi, Duck Joo; Kim, Ju Hyun
- Issue Date
- May-2014
- Publisher
- KOREAN ASSOC INTERNAL MEDICINE
- Keywords
- Hepatitis B; Korea; Vaccination; Vertical infection transmission
- Citation
- KOREAN JOURNAL OF INTERNAL MEDICINE, v.29, no.3, pp.307 - 314
- Journal Title
- KOREAN JOURNAL OF INTERNAL MEDICINE
- Volume
- 29
- Number
- 3
- Start Page
- 307
- End Page
- 314
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12675
- DOI
- 10.3904/kjim.2014.29.3.307
- ISSN
- 1226-3303
- Abstract
- Background/Aims: The Ministry of Health and Welfare and the Korea Centers for Disease Control and Prevention in South Korea have been organizing hepatitis B virus (HBV) vertical infection prevention projects since July 2002. In this single-institute study, the results of surveys conducted in target mothers who delivered babies in a tertiary hospital were investigated and analyzed. Methods: Of the 9,281 mothers and their 9,824 neonates born between July 2002 and December 2012, 308 hepatitis B surface antigen (HBsAg)-positive mothers and their 319 neonates were selected for this study, and their records were analyzed retrospectively. Results: A total of 308 mothers were HBsAg-positive, with an HBV prevalence of 3.32% (308/9,281). There were 319 neonates born to these HBsAg-positive mothers, and 252 were confirmed to as either HBsAg-positive or -negative. Four were confirmed as HBsAg-positive, with a 1.59% (4/252) HBV vertical infection rate. All the mothers of neonates who had an HBV vertical infection were hepatitis B e antigen (HBeAg)-positive. Among the HBsAg-positive neonates, three were HBeAg-positive and had an HBV DNA titer of 1.0 x 10(8) copies/mL. Conclusions: The HBV prevalence of mothers was 3.32% (308/9,284 and their vertical infection rate was 1.59% (4/252). Thus, the South Korean HBV vertical infection prevention projects are effective, and, accordingly, HBV prevalence in South Korea is expected to decrease continuously.
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