Immunosuppressive effects of fisetin against dinitrofluorobenzene-induced atopic dermatitis-like symptoms in NC/Nga mice
- Authors
- Kim, Gun-Dong; Lee, Seung Eun; Park, Yong Seek; Shin, Dong-Hoon; Park, Gwi Gun; Park, Cheung-Seog
- Issue Date
- Apr-2014
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Atopic dermatitis; Fisetin; 2-4-Dinitrofluorobenzene; NC/Nga; NF-kappa B
- Citation
- FOOD AND CHEMICAL TOXICOLOGY, v.66, pp.341 - 349
- Journal Title
- FOOD AND CHEMICAL TOXICOLOGY
- Volume
- 66
- Start Page
- 341
- End Page
- 349
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12724
- DOI
- 10.1016/j.fct.2014.01.057
- ISSN
- 0278-6915
- Abstract
- Atopic dermatitis (AD) is a multifactorial chronic skin disorder that is increasing in prevalence globally. In NC/Nga mice, repetitive epicutaneous applications of 2-4-dinitrofluorobenzene (DNFB) induces AD-like clinical symptoms. Bioflanonol fisetin (3,7,3',4'-tetrahydroxyflavone) is a dietary component found in plants, fruits and vegetables. Fisetin has various physiological effects that include anti-oxidation, antiangiogenesis, anti-carcinogenesis and anti-inflammation. In this study, we investigated whether fisetin relieves AD-like clinical symptoms induced by repeated DNFB treatment in NC/Nga mice. Fisetin significantly inhibited infiltration of inflammatory cells including eosinophils, mast cells and CD4(+) T and CD8(+) T cells, and suppressed the expressions of cytokines and chemokines associated with dermal infiltrates in AD-like skin lesions. Total serum immunoglobulin E (IgE) levels and the ratio of phospho-NF-kappa B p65 to total NF-kappa B p65 were markedly reduced by fisetin. Fisetin also reduced the production of interferon-gamma and interleukin-4 by activated CD4(+) T cells in a dose-dependent manner, whereas the anti-inflammatory cytokine, interleukin-10 was increased. These results implicate fisetin as a potential therapeutic for AD. (C) 2014 Elsevier Ltd. All rights reserved.
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