A comparison of the clinical outcomes of patients with invasive lobular carcinoma and invasive ductal carcinoma of the breast according to molecular subtype in a Korean population
- Authors
- Lim, Seung Taek; Yu, Jong Han; Park, Heung Kyu; Moon, Byung In; Ko, Byung Kyun; Suh, Young Jin
- Issue Date
- 13-Mar-2014
- Publisher
- BMC
- Keywords
- Invasive lobular carcinoma; Invasive ductal carcinoma; Molecular subtype; Breast cancer-specific survival; Overall survival
- Citation
- WORLD JOURNAL OF SURGICAL ONCOLOGY, v.12
- Journal Title
- WORLD JOURNAL OF SURGICAL ONCOLOGY
- Volume
- 12
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12783
- DOI
- 10.1186/1477-7819-12-56
- ISSN
- 1477-7819
- Abstract
- Background: To investigate the clinicopathological characteristics and the survival outcomes of invasive lobular carcinoma (ILC) patients compared to invasive ductal carcinoma (IDC) patients according to their molecular subtype. Methods: We compared the clinicopathological characteristics, breast cancer-specific survival (BCSS) and overall survival (OS) between patients with IDC (n = 14,547) and ILC (n = 528). Results: The ILC presented with a larger tumor size, more advanced cancer stage, increased rate of hormonal receptor positivity, human epidermal growth factor 2 (HER2) negativity and mastectomy than the IDC. The ILC patients more frequently presented with the luminal A subtype, whereas the IDC patients more frequently presented with the luminal B, HER2-overexpression, or triple negative subtype. The BCSS and OS were not significantly different between the IDC and ILC for each molecular subtype. Conclusions: Similar to IDC patients, molecular subtype should be considered when determining the prognosis and treatment regimen for ILC patients.
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