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Dehydroevodiamine center dot HCl Improves Stress-Induced Memory Impairments and Depression Like Behavior in Rats

Authors
Kim, Hee JinShin, Ki YoungChang, Keun-AAhn, SangzinChoi, Hee SoonKim, Hye-SunSuh, Yoo-Hun
Issue Date
Feb-2014
Publisher
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
Keywords
Depression; DHED; Fluoxetine; Memory; Stress
Citation
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.18, no.1, pp.55 - 59
Journal Title
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
Volume
18
Number
1
Start Page
55
End Page
59
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12851
DOI
10.4196/kjpp.2014.18.1.55
ISSN
1226-4512
Abstract
Dehydroevodiamine center dot HCl (DHED) has been reported to prevent memory impairment and neuronal cell loss in a rat model with cognitive disturbance. We investigated the effect of DHED on memory impairment and behavioral abnormality caused by stress. We demonstrated that DHED can improve stress-induced memory impairments and depression-like behaviors by using open-field test, Y-maze test and forced swimming test. DHED treatment significantly recovered the decreases in the levels of neural cell adhesion molecule (NCAM) proteins caused by stress and the decreases in cell viability. Our results suggested that DHED is a potential drug candidate for neuronal death, memory impairment and depression induced by stress.
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