3'-Deoxy-3'-[F-18]Fluorothymidine Positron Emission Tomography Imaging of Thymidine Kinase 1 Activity After 5-Fluorouracil Treatment in a Mouse Tumor Model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Il Ki | - |
dc.contributor.author | Kim, Seog Young | - |
dc.contributor.author | Chung, Jin Hwa | - |
dc.contributor.author | Lee, Seung Jin | - |
dc.contributor.author | Oh, Seung Jun | - |
dc.contributor.author | Lee, Sang Ju | - |
dc.contributor.author | Oh, Jungsu | - |
dc.contributor.author | Ryu, Jin-Sook | - |
dc.contributor.author | Kim, Tae Won | - |
dc.contributor.author | Kim, Deog Yoon | - |
dc.contributor.author | Moon, Dae Hyuk | - |
dc.date.available | 2020-02-28T18:42:27Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-02 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12875 | - |
dc.description.abstract | Aim: We aimed to investigate whether 3'-deoxy-3'-[F-18]fluorothymidine ([F-18]FLT) positron emission tomography (PET) can estimate thymidine kinase 1 (TK1) activity after thymidylate synthase (TS) inhibition by 5-fluorouracil (5-FU) in a mouse tumor model. Materials and Methods: Nude mice with HT29 tumors were injected with phosphate-buffered saline or 5-FU (16.7 or 50 mg/kg). Twenty-four hours later, 2-hour dynamic images were acquired after injection of [F-18]FLT. In another group of mice with HT29 cells, static PET images were obtained 110 min after [F-18]FLT injection. Results: Kinetic parameters related to [F-18]FLT retention increased significantly, whereas the de-phosphorylation of [F-18]FLT monophosphate decreased significantly. The standardized uptake value (SUVmean) of HT29 tumors correlated significantly with the net influx constant and the distribution volume for phosphorylated [F-18]FLT. There was a significant correlation between the tumor SUVmean and TK1 activity. Conclusion: SUVmean at 110-120 mm after [F-18]FLT, can quantitatively evaluate kinetic parameters and TK1 activity after TS inhibition. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | INT INST ANTICANCER RESEARCH | - |
dc.relation.isPartOf | ANTICANCER RESEARCH | - |
dc.subject | THYMIDYLATE SYNTHASE INHIBITION | - |
dc.subject | METASTATIC COLORECTAL-CANCER | - |
dc.subject | SUBSTRATE CYCLES | - |
dc.subject | IN-VIVO | - |
dc.subject | CELLS | - |
dc.subject | CHEMOTHERAPY | - |
dc.subject | LEUCOVORIN | - |
dc.subject | NUCLEOSIDE | - |
dc.subject | METABOLISM | - |
dc.subject | THERAPY | - |
dc.title | 3'-Deoxy-3'-[F-18]Fluorothymidine Positron Emission Tomography Imaging of Thymidine Kinase 1 Activity After 5-Fluorouracil Treatment in a Mouse Tumor Model | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000331497200028 | - |
dc.identifier.bibliographicCitation | ANTICANCER RESEARCH, v.34, no.2, pp.759 - 766 | - |
dc.identifier.scopusid | 2-s2.0-84897098561 | - |
dc.citation.endPage | 766 | - |
dc.citation.startPage | 759 | - |
dc.citation.title | ANTICANCER RESEARCH | - |
dc.citation.volume | 34 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Lee, Seung Jin | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | 3&apos | - |
dc.subject.keywordAuthor | -deoxy-3&apos | - |
dc.subject.keywordAuthor | -[18F]fluorothymidine | - |
dc.subject.keywordAuthor | positron emission tomography | - |
dc.subject.keywordAuthor | thymidine kinase | - |
dc.subject.keywordAuthor | 5-fluorouracil | - |
dc.subject.keywordAuthor | thymidylate synthase | - |
dc.subject.keywordPlus | THYMIDYLATE SYNTHASE INHIBITION | - |
dc.subject.keywordPlus | METASTATIC COLORECTAL-CANCER | - |
dc.subject.keywordPlus | SUBSTRATE CYCLES | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | LEUCOVORIN | - |
dc.subject.keywordPlus | NUCLEOSIDE | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | THERAPY | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.