Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pigmentation in Guinea Pig Skin
DC Field | Value | Language |
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dc.contributor.author | Lee, Taek Hwan | - |
dc.contributor.author | Seo, Jae Ok | - |
dc.contributor.author | Baek, So-Hyeon | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.date.available | 2020-02-28T18:42:38Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014-01-31 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12884 | - |
dc.description.abstract | Resveratrol is a polyphenolic compound found in various natural products such as grapes and berries and possesses anti-cancer, anti-hyperlipidemia, and anti-aging properties. Recently, it has been reported that resveratrol inhibits a-melanocyte-stimulating hormone signaling, viability, and migration in melanoma cells. However, these effects have not been confirmed in vivo, specifically brownish guinea pigs. To evaluate the potential of resveratrol as a regulator of melanin for hyperpigmentation therapy, the influence of resveratrol on pigmentation was investigated by ultraviolet B-induced hyperpigmentation in brownish guinea pig skin. We found that resveratrol reduced the expression of melanogenesis-related proteins tyrosinase, tyrosinase-related proteins 1 and 2, and microphthalmia-associated transcription factor in melanoma cells. Furthermore, topical application of resveratrol was demonstrated to significantly decrease hyperpigmentation on ultraviolet B-stimulated guinea pig skin in vivo. Based on our histological data, resveratrol inhibits melanin synthesis via a reduction in tyrosinase-related protein 2 among the melanogenic enzymes. This study is the first to provide evidence supporting resveratrol as a depigmentation agent, along with further clinical investigation of resveratrol in ultraviolet B-induced skin disorders such as hyperpigmentation and skin photoaging. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC APPLIED PHARMACOLOGY | - |
dc.relation.isPartOf | BIOMOLECULES & THERAPEUTICS | - |
dc.subject | TYROSINASE | - |
dc.subject | EXPRESSION | - |
dc.subject | OXIDASE | - |
dc.subject | CELLS | - |
dc.subject | TRP1 | - |
dc.title | Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pigmentation in Guinea Pig Skin | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000330818200005 | - |
dc.identifier.doi | 10.4062/biomolther.2013.081 | - |
dc.identifier.bibliographicCitation | BIOMOLECULES & THERAPEUTICS, v.22, no.1, pp.35 - 40 | - |
dc.identifier.kciid | ART001846727 | - |
dc.identifier.scopusid | 2-s2.0-84893035914 | - |
dc.citation.endPage | 40 | - |
dc.citation.startPage | 35 | - |
dc.citation.title | BIOMOLECULES & THERAPEUTICS | - |
dc.citation.volume | 22 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Seo, Jae Ok | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Resveratrol | - |
dc.subject.keywordAuthor | Depigmentation | - |
dc.subject.keywordAuthor | Hyperpigmentation | - |
dc.subject.keywordAuthor | Melanogenesis | - |
dc.subject.keywordAuthor | Guinea pig | - |
dc.subject.keywordAuthor | Ultraviolet B | - |
dc.subject.keywordPlus | TYROSINASE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | OXIDASE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TRP1 | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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