Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pigmentation in Guinea Pig Skin
- Authors
- Lee, Taek Hwan; Seo, Jae Ok; Baek, So-Hyeon; Kim, Sun Yeou
- Issue Date
- 31-Jan-2014
- Publisher
- KOREAN SOC APPLIED PHARMACOLOGY
- Keywords
- Resveratrol; Depigmentation; Hyperpigmentation; Melanogenesis; Guinea pig; Ultraviolet B
- Citation
- BIOMOLECULES & THERAPEUTICS, v.22, no.1, pp.35 - 40
- Journal Title
- BIOMOLECULES & THERAPEUTICS
- Volume
- 22
- Number
- 1
- Start Page
- 35
- End Page
- 40
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12884
- DOI
- 10.4062/biomolther.2013.081
- ISSN
- 1976-9148
- Abstract
- Resveratrol is a polyphenolic compound found in various natural products such as grapes and berries and possesses anti-cancer, anti-hyperlipidemia, and anti-aging properties. Recently, it has been reported that resveratrol inhibits a-melanocyte-stimulating hormone signaling, viability, and migration in melanoma cells. However, these effects have not been confirmed in vivo, specifically brownish guinea pigs. To evaluate the potential of resveratrol as a regulator of melanin for hyperpigmentation therapy, the influence of resveratrol on pigmentation was investigated by ultraviolet B-induced hyperpigmentation in brownish guinea pig skin. We found that resveratrol reduced the expression of melanogenesis-related proteins tyrosinase, tyrosinase-related proteins 1 and 2, and microphthalmia-associated transcription factor in melanoma cells. Furthermore, topical application of resveratrol was demonstrated to significantly decrease hyperpigmentation on ultraviolet B-stimulated guinea pig skin in vivo. Based on our histological data, resveratrol inhibits melanin synthesis via a reduction in tyrosinase-related protein 2 among the melanogenic enzymes. This study is the first to provide evidence supporting resveratrol as a depigmentation agent, along with further clinical investigation of resveratrol in ultraviolet B-induced skin disorders such as hyperpigmentation and skin photoaging.
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