Pretransplant mortality predictors in living and deceased donor liver transplantation

Abstract

Background: Although there were some reports predicting postoperative morbidity and mortality in patients undergoing liver transplantation, most of them studied deceased-donor liver transplantation (DDLT). In this context, we performed this study to predict early mortality after liver transplantation from preoperative variables in both living-donor liver transplantation (LDLT) and DDLT. Methods: We retrospectively reviewed the medical charts of 159 patients undergoing liver transplantation (LDLT, n = 103; DDLT, n = 56). Then, we identified the factors that independently predicted 30-day mortality using multivariable logistic regression models. Results: The 30-day mortality and 1-year mortality for DDLT versus LDLT were 30% versus 6% and 39% versus 11%, respectively. In multivariate logistic regression analysis, pretransplant hepatic encephalopathy (odds ratio, 5.594; 95% confidence interval, 1.110-28.194; p = 0.037) in patients with DDLT and serum creatinine (odds ratio, 4.883; 95% confidence interval, 1.296-18.399; p = 0.019) in patients with LDLT were the independent risk factors for a composite of 30-day mortality. Conclusion: In conclusion, hepatic encephalopathy in DDLT and serum creatinine level in LDLT were the significant pretransplant variables that were related with early death after LT. Copyright (C) 2013 Elsevier Taiwan LLC and the Chinese Medical Association. All rights reserved.