Correction of Anemia with Continuous Erythropoietin Receptor Activator in Korean Patients on Long-Term Hemodialysis
- Authors
- Oh, Jieun; Joo, Kwon-Wook; Chin, Ho-Jun; Chae, Dong-Wan; Kim, Sung-Gyun; Kim, Soo Jin; Chung, Wookyung; Kim, Sejoong; Huh, Wooseong; Oh, Ha Young; Choi, Bum Soon; Yang, Chul-Woo; Kim, Suhnggwon
- Issue Date
- Jan-2014
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Anemia Correction; Continuous Erythropoietin Receptor Activator; Kidney Failure, Chronic; Renal Dialysis
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.29, no.1, pp.76 - 83
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 29
- Number
- 1
- Start Page
- 76
- End Page
- 83
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/12957
- DOI
- 10.3346/jkms.2014.29.1.76
- ISSN
- 1011-8934
- Abstract
- Continuous erythropoietin receptor activator (CERA) is an erythropoietin with a long-half life. This study investigated the efficacy of CERA for correcting anemia in Korean patients on dialysis. Patients (>= 18 yr) who were not receiving any ESAs for more than 8 weeks were randomly assigned to either intravenous CERA once every 2 weeks (n = 39) or epoetin beta thrice-weekly (n = 41) during a 24-week correction phase. Hemoglobin (Hb) response was defined as increase of Hb by at least 1 g/dL and Hb >= 11 g/dL without red blood cell (RBC) transfusion. Median dialysis duration was 1.7 (0.3-20.8) and 1.6 (0.4-13.8) yr in CERA and epoetin beta group, respectively. Hemoglobin response rate of CERA was 79.5% (95% confidence interval [CI], 63.5-90.7). As the lower limit of 95% CI was higher than pre-specified 60% response rate, it can be concluded that CERA corrected anemia (P < 0.05). Hb response rate of epoetin beta was 87.8% (95% CI, 73.8-95.9) (P = 0.37). Median time to response was 12 weeks in CERA and 10.3 weeks in epoetin beta (P = 0.03). It is suggested that once every 2 weeks administration of CERA is effective for correcting anemia in Korean patients on long-term hemodialysis with longer time-to-response than thrice weekly epoetin beta.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.