Phytochemical constituents of Salsola komarovii and their effects on NGF induction
- Authors
- Cho, H.K.; Suh, W.S.; Kim, K.H.; Kim, S.Y.; Lee, K.R.
- Issue Date
- Jun-2014
- Publisher
- Korean Society of Pharmacognosy
- Keywords
- Chemopodiaceae; Lignan; NGF regulation; Salsola komarovii
- Citation
- Natural Product Sciences, v.20, no.2, pp.95 - 101
- Journal Title
- Natural Product Sciences
- Volume
- 20
- Number
- 2
- Start Page
- 95
- End Page
- 101
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13042
- ISSN
- 1226-3907
- Abstract
- Five lignan glycosides, seven megastigmane glycosides, and seven phenolic compounds were isolated by repeated column chromatography from the MeOH extract of Salsola komarovii. Their structures were determined to be lariciresinol-9-O-β-D-glucopyranoside (1), alangilignoside C (2), conicaoside (3), (+)- lyoniresinol 9'-O-β-D-glucopyranoside (4), (8S,8'R,7'R)-9'-[(β-glucopyranosyl)oxy]lyoniresinol (5), blumenyl B β- D-glucopyranoside (6), blumenyl A β-D-glucopyranoside (7), staphylionoside D (8), icariside B2 (9), (6R,9S)-3- oxo-α-ionol β-D-glucopyranoside (10), 3-oxo-α-ionol 9-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (11), blumenol B 9-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (12), benzyl 6-O-β-D-apiofuranosyl-β-Dglucopyranoside (13), canthoside C (14), tachioside (15), isotachioside (16), biophenol 2 (17), 2-(3,4-dihydroxy)- phenyl-ethyl-β-D-glucopyranoside (18), and cuneataside C (19) by spectroscopic methods. All the isolated compounds 1 - 19 were reported from this source for the first time. Compounds 2, 3 and 6 upregulated NGF secretion to 118.8 ± 3.6%, 128.2 ± 9.3% and 111.1 ± 7.1% without significant cell toxicity. © 2014, Korean Society of Pharmacognosy. All Rights Reserved.
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