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Screening of Chinese Herbal Medicines with Inhibitory Effect on Aldose Reductase (X)중국 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색(X)
- Other Titles
- 중국 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색(X)
- Authors
- Choi, S.-J.; Kim, Y.S.; Kim, J.H.; Kim, J.S.
- Issue Date
- Dec-2014
- Publisher
- Korean Society of Pharmacognosy
- Keywords
- Aldose reductase inhibitor; Chinese herbal medicines; Diabetic complications
- Citation
- Korean Journal of Pharmacognosy, v.45, no.4, pp.359 - 365
- Journal Title
- Korean Journal of Pharmacognosy
- Volume
- 45
- Number
- 4
- Start Page
- 359
- End Page
- 365
- ISSN
- 0253-3073
- Abstract
- Aldose reductase (AR) is the key enzyme of the polyol pathway in the development of the diabetic complications. Sixty seven Chinese herbal medicines have been investigated for inhibitory activities on AR. Among them, 7 herbal medicines, Buddleja crispa (twigs and leaves), Taiwania flousiana (twigs and leaves), Sloanea hemsleyana (fruits), Euphorbia nemetocypha (whole plants), Photinia glomerata (twigs and leaves), Vitex yunnanensis (twigs and leaves) exhibited a significant inhibitory activity against AR. Particularly, S. hemsleyana and V. yunnanensis showed 1.2-4.5 times more potent inhibitory activity than the positive control, 3,3-tetramethyleneglutaric acid (TMG). © 2015, Korean Society of Pharmacognosy. All rights reserved.
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Related Researcher
- Kim, Joo-Hwan
- BioNano Technology (Department of Life Sciences)