Effect of pneumoperitoneum on the recovery from intense neuromuscular blockade by rocuronium in healthy patients undergoing laparoscopic surgery
- Authors
- Kim, H.S.; Lee, D.C.; Lee, M.G.; Son, W.R.; Kim, Y.B.
- Issue Date
- 2014
- Publisher
- Korean Society of Anesthesiologists
- Keywords
- Neuromuscular blockade; Neuromuscular monitoring; Pneumoperitoneum; Rocuronium
- Citation
- Korean Journal of Anesthesiology, v.67, no.1, pp.20 - 25
- Journal Title
- Korean Journal of Anesthesiology
- Volume
- 67
- Number
- 1
- Start Page
- 20
- End Page
- 25
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13086
- DOI
- 10.4097/kjae.2014.67.1.20
- ISSN
- 2005-6419
- Abstract
- Background: This study investigated the effect of pneumoperitoneum on the recovery from intense neuromuscular blockade by rocuronium in healthy patients undergoing laparoscopic abdominal surgery. Methods: Thirty adult patients undergoing laparoscopic abdominal surgery were studied. Anesthesia was induced with 1.5 mg/kg of propofol, 12 ug/kg of alfentanil and 0.6 mg/kg of rocuronium and maintained with 2 vol% of sevoflurane and 0.05-0.2 μg/kg/min remifentanil. The neuromuscular relaxation was monitored by Train-of-Four (TOF) and post-tetanic count (PTC). Additional rocuronium of 0.2 mg/kg was administered for deep neuromuscular blockade at 30 min after pneumoperitoneum. Before (PPpre) and 30 min after pneumoperitoneum (PPpost), PTC was measured at 6 min intervals. The relationship between PTC and the time interval to reappearance of T1 response was observed. Results: The mean ± SD of the intervals between the detection of 4 counts of the PTC and the first response to TOF stimulation was 13.0 ± 1.1 min and 16.4 ± 6.3 min PPpre and PPpost, respectively (P = 0.20). There were significant negative relationships between PTC observed and the time interval to reappearance of T1 response (adjusted R2 = 0.869, P < 0.001 for PPpre data, and adjusted R2 = 0.561, P < 0.001 for PPpost data). Comparing the difference of regression equation between PPpre and PPpost data using a parallelism test, there was no statistically significant difference (P = 0.193). Conclusions: This study showed that PP with intra-abdominal pressure at the level of 13-14 mmHg did not affect the recovery from intense neuromuscular blockade by rocuronium in healthy patients undergoing laparoscopic abdominal surgery. © the Korean Society of Anesthesiologists, 2014.
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