Ten day concomitant therapy is superior to ten day sequential therapy for Helicobacter pylori eradication10일간의 동시치료가 10일간의 순차치료보다 헬리코박터 파일로리 제균율이 우월하다
- Other Titles
- 10일간의 동시치료가 10일간의 순차치료보다 헬리코박터 파일로리 제균율이 우월하다
- Authors
- Kim, S.Y.; Park, D.K.; Kwon, K.A.; Kim, K.O.; Kim, Y.J.; Chung, J.W.
- Issue Date
- Nov-2014
- Publisher
- 대한소화기학회
- Keywords
- Helicobacter pylori; Eradication; First-line regimen; 헬리코박터 파일로리; 제균; 일차 제균 요법
- Citation
- The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, v.64, no.5, pp.260 - 267
- Journal Title
- The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
- Volume
- 64
- Number
- 5
- Start Page
- 260
- End Page
- 267
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13153
- DOI
- 10.4166/kjg.2014.64.5.260
- ISSN
- 1598-9992
- Abstract
- BACKGROUND/AIMS: Because the efficacy of standard triple therapy for Helicobacter pylori eradication has declined, new regimens such as sequential therapy (ST) and concomitant therapy (CoCTx) have been introduced. The aim of this study was to compare the efficacy of 10-day ST and 10-day CoCTx for H. pylori eradication.METHODS: We retrospectively reviewed the medical records of 316 patients with proven H. pylori infection. They were assigned to one of 2 regimens; ST (n=191) consisted of, lansoprazole 30 mg and amoxicillin 1 g for 5 days followed by lansoprazole 30 mg, metronidazole 500 mg, and clarithromycin 500 mg for 5 days, and CoCTx (n=125) consisted of lansoprazole 30 mg, amoxicillin 1 g, metronidazole 500 mg, and clarithromycin 500 mg for 10 days. All drugs were administered twice a day. Bacterial eradication was checked by using a (13)C-urea breath test at least 4 weeks after completion of treatment.RESULTS: The mean age and male to female ratio was 51.74 and 1.03, respectively. Baseline characteristics were not different in both groups. Ten day CoCTx group (94.4%, 118/125) showed better eradication rate than ST group (82.2%, 157/191) (p=0.002). Drug compliances were not statistically different between the two groups (p=0.19). Side effects were more frequently reported in the CoCTx group than in the ST group (p=0.03).CONCLUSIONS: Ten-day CoCTx was superior to ST in terms of eradicating H. pylori infection. Although the CoCTx producing more side effects than ST, CoCTx can be thought to be a promising alternative to ST as a treatment regimen for H. pylori eradication.
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