The feasibility and efficacy of gonadotropin-releasing hormone agonists for prevention of chemotherapy induced ovarian failure in patient with gynecological malignancies
- Authors
- 박찬용; 정선영; 이광범; 양선혜
- Issue Date
- Nov-2014
- Publisher
- 대한산부인과학회
- Keywords
- Adjuvant chemotherapy; Fertility preservation; Gonadotropin releasing hormone agonist; Ovarian neoplasms; Uterine cervical neoplasms
- Citation
- Obstetrics & Gynecology Science, v.57, no.06, pp.478 - 483
- Journal Title
- Obstetrics & Gynecology Science
- Volume
- 57
- Number
- 06
- Start Page
- 478
- End Page
- 483
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13376
- DOI
- 10.5468/ogs.2014.57.6.478
- ISSN
- 2287-8572
- Abstract
- ObjectiveTo assess the effects of a gonadotropin-releasing hormone agonist (GnRH-a) depot (Leuprolide acetate) in women with gynecologic cancer receiving chemotherapy while taking a continuous add-back on the prevention of premature ovarian failure.
MethodsFourteen premenopausal patients with gynecological malignancies who had undergone conservation of ovaries surgery received a GnRH-a depot plus add-back until chemotherapy was completed. Four weeks thereafter, a hormonal profile (follicle stimulating hormone) was measured.
ResultsThe mean follicle stimulating hormone level was 15.8 IU/L. All patients exhibited a restoration of ovarian failure during follow-up. One patient became pregnant during the follow-up period.
ConclusionIn the short term, GnRH-a appears to protect ovarian function and ability to achieve pregnancy following chemotherapy. The result of our study needs further elucidation in a large randomized controlled trial.
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Collections - 의과대학 > 의학과 > 1. Journal Articles
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