Human papillomavirus 18 as a poor prognostic factor in stage I-IIA cervical cancer following primary surgical treatment
- Authors
- 양선혜; 공수경; 이승호; 임소이; 박찬용
- Issue Date
- Nov-2014
- Publisher
- 대한산부인과학회
- Keywords
- Genotype; Human papillomavirus; Prognosis; Uterine cervical neoplasms
- Citation
- Obstetrics & Gynecology Science, v.57, no.06, pp.492 - 500
- Journal Title
- Obstetrics & Gynecology Science
- Volume
- 57
- Number
- 06
- Start Page
- 492
- End Page
- 500
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13381
- DOI
- 10.5468/ogs.2014.57.6.492
- ISSN
- 2287-8572
- Abstract
- ObjectiveThis study evaluates the effect of the specific human papillomavirus (HPV) genotype as a prognostic factor in stage I-IIA cervical cancer patients following primary surgical treatment.
MethodsThe medical records of 116 cervical cancer patients treated with primary surgical treatment were reviewed. The HPV genotypes were categorized into following groups: negative and unclassified, HPV 16, HPV 18, and other high risk (HPV 31, 33, 35, 45, 51, 52, 56, and 58).
ResultsAmong the HPV genotypes, HPV 16 predominated(40.52%), followed by intermediate risk and unclassified (25%), HPV 18, 45, and 56 (17.24%) and negative (17.24%). In univariate analysis, HPV genotypes (P=0.03), parametrial spread (P=0.02), depth of invasion (DOI) (P<0.01) and lymph-vascular space invasion (P=0.02) were significantly associated with progression free survival (PFS). In multivariate analysis, HPV 18 (hazard ratio [HR], 5.2; 95% confidence interval [CI], 1.29 to 20.90; P=0.02) and ≥one half of DOI (HR, 5.4; 95% CI, 1.08 to 27.31; P=0.04) were significantly associated with PFS. HPV genotypes are not significantly associated with overall survival.
ConclusionHPV 18 was a poor prognostic factor for the PFS in stage I-IIA cervical cancer patients following primary surgical treatment. Careful long-term observation and regular exams are recommended for cervical cancer patients with HPV 18 compared to those with other HPV genotypes.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13381)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.