No influence of parental origin of intact X chromosome and/or Y chromosome sequences on three-year height response to growth hormone therapy in Turner syndrome
DC Field | Value | Language |
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dc.contributor.author | 이혜진 | - |
dc.contributor.author | 정혜운 | - |
dc.contributor.author | 이경민 | - |
dc.contributor.author | 김화영 | - |
dc.contributor.author | 김재현 | - |
dc.contributor.author | 이선희 | - |
dc.contributor.author | 김지현 | - |
dc.contributor.author | 이영아 | - |
dc.contributor.author | 신충호 | - |
dc.contributor.author | 양세원 | - |
dc.date.available | 2020-02-28T20:41:26Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1226-2242 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13449 | - |
dc.description.abstract | Purpose: Whether parental origin of the intact X chromosome and/or the presence of Y chromosome sequences (Yseq) play a role in three-year height response to growth hormone (GH) were investigated. Methods: Paternal (Xp) or maternal (Xm) origin of X chromosome was assessed by microsatellite marker analysis and the presence of hidden Yseq was analyzed. The first-, second-, and third-year GH response was measured as a change in height z-score (Z_Ht) in Turner syndrome (TS) patients with 45,Xp (n=10), 45,Xm (n=15), and 45,X/46,X,+mar(Y) (Xm_Yseq) (n=8). Results: The mean baseline Z_Ht did not differ according to Xp or Xm origin, however the mean baseline Z_Ht was higher in the Xm_Yseq group than in Xm group, after adjusting for bone age delay and midparental Z_Ht (P=0.04). There was no difference in the height response to GH between the 3 groups. The height response to GH decreased progressively each year (P<0.001), such that the third- year increase in Z_Ht was not significant. This third-year decrease in treatment response was unaffected by Xp, Xm, and Xm_Yseq groups. Increasing GH dosage from the second to third-year of treatment positively correlated with the increase in Z_Ht (P=0.017). Conclusion: There was no evidence of X-linked imprinted genes and/or Yseq affecting height response to 3 years of GH therapy. Increasing GH dosages may help attenuate the decrease in third-year GH response in TS patients with 45,X and/or 46,X/+mar(Y). | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한소아내분비학회 | - |
dc.relation.isPartOf | Annals of Pediatirc Endocrinology & Metabolism | - |
dc.title | No influence of parental origin of intact X chromosome and/or Y chromosome sequences on three-year height response to growth hormone therapy in Turner syndrome | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | Annals of Pediatirc Endocrinology & Metabolism, v.19, no.3, pp.127 - 134 | - |
dc.identifier.kciid | ART001917784 | - |
dc.citation.endPage | 134 | - |
dc.citation.startPage | 127 | - |
dc.citation.title | Annals of Pediatirc Endocrinology & Metabolism | - |
dc.citation.volume | 19 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | 이선희 | - |
dc.subject.keywordAuthor | Turner syndrome | - |
dc.subject.keywordAuthor | Growth hormone | - |
dc.subject.keywordAuthor | X chromosome | - |
dc.subject.keywordAuthor | Y chromosome | - |
dc.subject.keywordAuthor | Genomic imprinting | - |
dc.description.journalRegisteredClass | kci | - |
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