No influence of parental origin of intact X chromosome and/or Y chromosome sequences on three-year height response to growth hormone therapy in Turner syndrome
- Authors
- 이혜진; 정혜운; 이경민; 김화영; 김재현; 이선희; 김지현; 이영아; 신충호; 양세원
- Issue Date
- 2014
- Publisher
- 대한소아내분비학회
- Keywords
- Turner syndrome; Growth hormone; X chromosome; Y chromosome; Genomic imprinting
- Citation
- Annals of Pediatirc Endocrinology & Metabolism, v.19, no.3, pp.127 - 134
- Journal Title
- Annals of Pediatirc Endocrinology & Metabolism
- Volume
- 19
- Number
- 3
- Start Page
- 127
- End Page
- 134
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13449
- ISSN
- 1226-2242
- Abstract
- Purpose: Whether parental origin of the intact X chromosome and/or the presence of Y chromosome sequences (Yseq) play a role in three-year height response to growth hormone (GH) were investigated.
Methods: Paternal (Xp) or maternal (Xm) origin of X chromosome was assessed by microsatellite marker analysis and the presence of hidden Yseq was analyzed. The first-, second-, and third-year GH response was measured as a change in height z-score (Z_Ht) in Turner syndrome (TS) patients with 45,Xp (n=10), 45,Xm (n=15), and 45,X/46,X,+mar(Y) (Xm_Yseq) (n=8).
Results: The mean baseline Z_Ht did not differ according to Xp or Xm origin, however the mean baseline Z_Ht was higher in the Xm_Yseq group than in Xm group, after adjusting for bone age delay and midparental Z_Ht (P=0.04). There was no difference in the height response to GH between the 3 groups. The height response to GH decreased progressively each year (P<0.001), such that the third- year increase in Z_Ht was not significant. This third-year decrease in treatment response was unaffected by Xp, Xm, and Xm_Yseq groups. Increasing GH dosage from the second to third-year of treatment positively correlated with the increase in Z_Ht (P=0.017).
Conclusion: There was no evidence of X-linked imprinted genes and/or Yseq affecting height response to 3 years of GH therapy. Increasing GH dosages may help attenuate the decrease in third-year GH response in TS patients with 45,X and/or 46,X/+mar(Y).
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 간호대학 > 간호학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13449)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.