황련해독탕(黃連解毒湯)이 외열 스트레스(火邪)에 의한 동물모델에서 c-fos 발현에 미치는 영향 연구
DC Field | Value | Language |
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dc.contributor.author | 황덕상 | - |
dc.contributor.author | 김효근 | - |
dc.contributor.author | 오명숙 | - |
dc.contributor.author | 김태미 | - |
dc.contributor.author | 이태희 | - |
dc.date.available | 2020-02-28T20:41:43Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1229-4292 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13465 | - |
dc.description.abstract | Objectives: Hwangryunhaedok-tang (HH) is a representative heat clearing multiherbprescription. We evaluated the protective effect of HH against heat stress exposure in mice. Methods: Six weeks old ICR mice were used for this study. After 43℃ heat stressfor 15 minutes, we evaluated the changes of motor activity and c-fos expressionlevel to determine the proper heat stress and evaluation time. The subjects weredivided into 4 groups (1. control group, 2. heat stress group with normal saline,3. heat stress group with administration of 100 mg/kg, and 4. heat stress group withadministration of 1000 mg/kg). After oral administration of HH once a day for 3 days,2, 3, 4 groups were exposed to 43℃ heat stress for 15 minutes. Then, we evaluatedthe motor activity for 120 minutes and analyzed the c-fos expression using westernblot. We investigated the effect of HH and its ingredients on c-fos expressions afterheat stress. The mice were administrated HH, Scutellariae Radix, Coptidis Rhizoma,Phellodendri Cortex, and Gardeniae Fructus for 3 days. After one hour of last treatment,the mice were exposed to heat stress at 43℃ for 15 min. After two hours, the hypothalamuswas dissociated and lysed to measure c-fos expression. Results: After oral administration of HH for 3 days, motor activity was recoveredinsignificantly. 100 mg/kg HH treatment reduced the c-fos expression after heat stressbut insignificantly. Among the ingredients of HH, Coptidis Rhizoma and ScutellariaeRadix treatment groups significantly reduced the c-fos after stress. Conclusions: These results show that Hwangryunhaedok-tang may be effectiveto reduce the heat stress response. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한한방부인과학회 | - |
dc.relation.isPartOf | 대한한방부인과학회지 | - |
dc.title | 황련해독탕(黃連解毒湯)이 외열 스트레스(火邪)에 의한 동물모델에서 c-fos 발현에 미치는 영향 연구 | - |
dc.title.alternative | The Effect of Hwangryunhaedok-tang on the c-fos Level in Mice Exposed to Heat Stress | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.doi | 10.15204/jkobgy.2014.27.3.001 | - |
dc.identifier.bibliographicCitation | 대한한방부인과학회지, v.27, no.3, pp.1 - 11 | - |
dc.identifier.kciid | ART001901703 | - |
dc.citation.endPage | 11 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | 대한한방부인과학회지 | - |
dc.citation.volume | 27 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | 이태희 | - |
dc.subject.keywordAuthor | Heat Stress | - |
dc.subject.keywordAuthor | Hwangryunhaedok-tang | - |
dc.subject.keywordAuthor | Motor Activity | - |
dc.subject.keywordAuthor | C-fos | - |
dc.subject.keywordAuthor | Coptidis Rhizoma | - |
dc.subject.keywordAuthor | Scutellariae Radix | - |
dc.description.journalRegisteredClass | kci | - |
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