중증 디곡신(Digoxin) 중독환자에서 Digoxin Immune Fab을 사용한 1례

Abstract

Digoxin is commonly used in treatment of various heartconditions, such as atrial fibrillation, atrial flutter, and sometimesheart failure. The therapeutic range of digoxin is narrow. Therefore, Digoxin toxicity is common. However,severe digoxin intoxication is uncommon. Many casesinvolving application of Digoxin immune Fab for digoxinintoxication in other countries have been reported. However, no cases have been reported in Korea. Wereported on one case, a 34-year-old male with acute andsevere digoxin intoxication who was treated with digibind . His chief complaint was gastrointestinal symptoms, includingnausea and vomiting. Electrocardiography (ECG)showed third degree atrioventricular (AV) block. After aninfusion of digibind , third degree AV block rhythm waschanged to first degree AV block. Nowadays, we can obtaina digoxin antidote from the national poisoning informationcenter. Therefore, we should actively consider applicationof Digoxin immune Fab in patients with severe digoxinintoxication.