동종이식으로 치료한 급성 골수성 백혈병 항암 치료 후골수 무형성증 1예

Abstract

Persistent bone marrow aplasia after intensive chemotherapy is uncommon, but is one of the fatal complications in patients withacute myeloid leukemia (AML). Although allogeneic hematopoietic stem cell transplantation (HSCT) is considered to becontraindicated for patients who have hematologic diseases with serious infections, such as bacterial septicemia or invasive fungaldiseases, combined with prolonged neutropenia due to frequent morbidity and mortality, such risks can be overcome bynon-myeloablative conditioning and best supportive care. Here, we report an AML patient with persistent marrow aplasia afterinduction therapy, treated successfully with reduced-intensity allogeneic HSCT despite severe bacterial and fungal infections.