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t(3;5)(q25;q34)를 동반한 소아 급성골수성백혈병 1예A Pediatric Case of Acute Myeloid Leukemia with t(3;5)(q25;q34)
- Other Titles
- A Pediatric Case of Acute Myeloid Leukemia with t(3;5)(q25;q34)
- Issue Date
- 2014
- Publisher
- 대한소아혈액종양학회
- Keywords
- Acute myeloid leukemia; t(3; 5)(q25; q34); NPM; MLF
- Citation
- Clinical Pediatric Hematology-Oncology, v.21, no.2, pp.149 - 152
- Journal Title
- Clinical Pediatric Hematology-Oncology
- Volume
- 21
- Number
- 2
- Start Page
- 149
- End Page
- 152
- ISSN
- 2233-5250
- Abstract
- Acute myeloid leukemia (AML) with t(3;5)(q25;q34), belonging to AML with myelodysplasia related changes according to WHO classification in 2008, is a subtype of AML that is particularly rare in children. NPM1/MLF1 fusion gene produced as a result of t(3;5)(q25;q34) was cloned, however, the exact mechanism of its role in leukemogenesis has not been clarified. Although this cytogenetic abnormality is regarded as an intermediate risk factor, its clinical significance is controversial until now. More cases need to be reported and investigated, therefore we present a case of AML with t(3;5)(q25;q34) in a 14-year-old girl with literature review.
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