괴화가 국소뇌혈류량에 미치는 영향Effects of Flos Sophora japonica Extract on the Changes of Cerebral Hemodynamics
- Other Titles
- Effects of Flos Sophora japonica Extract on the Changes of Cerebral Hemodynamics
- Authors
- 나영아; 이우식; 박성진
- Issue Date
- 2014
- Publisher
- (사)한국조리학회
- Keywords
- Flos Sophora japonica L.; Regional Cerebral Blood Flow; Blood Pressure; Laser-Doppler Flowmetry; 괴화; 국소뇌혈류량; 괴화의 효능; 괴화투여 쥐실험; 괴화의 작용
- Citation
- Culinary Science & Hospitality Research, v.20, no.5, pp.67 - 70
- Journal Title
- Culinary Science & Hospitality Research
- Volume
- 20
- Number
- 5
- Start Page
- 67
- End Page
- 70
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/13923
- ISSN
- 2466-0752
- Abstract
- The purpose of this study was to measure the changes of regional cerebral blood flow(rCBF) and blood pressure(BP) in rats, following the intravenous injection of Flos Sophora japonica L.(FSJ) water extract. The measurement was continually monitored by Laser-Doppler Flowmeter and pressure transducer in anaesthetized adult Sprague-Dawley rats for 2 hours to 2 hours and a half through the data acquisition system. FSJ increased the changes of rCBF in rat significantly. The rCBF of FSJ did not change by pretreated propranolol, atropine, L-NNA(NG-nitro-L-argininine) and indomethacin. But the rCBF of Flos Sophora japonica L. was increased by pretreated methylene blue. FSJ decreased the changes of BP, significantly. The BP of FSJ did not change by pretreated propranolol, atropine, L-NNA and indomethacin. But the BP FSJ was decreased by pretreated methylene blue. There results indicated that FSJ can increase the rCBF and decrease the BP, that is related to guanylyl cyclase activity.
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