Role of surface modification in zinc oxide nanoparticles and its toxicity assessment toward human dermal fibroblast cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ramasamy, Mohankandhasamy | - |
dc.contributor.author | Das, Minakshi | - |
dc.contributor.author | An, Seong Soo A. | - |
dc.contributor.author | Yi, Dong Kee | - |
dc.date.available | 2020-02-28T21:45:45Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14011 | - |
dc.description.abstract | The wide-scale applications of zinc oxide (ZnO) nanoparticles (NPs) in photocatalysts, gas sensors, and cosmetics may cause toxicity to humans and environments. Therefore, the aim of the present study was to reduce the toxicity of ZnO NPs by coating them with a silica (SiO2) layer, which could be used in human applications, such as cosmetic preparations. The sol-gel method was used to synthesize core ZnO with SiO2-shelled NPs (SiO2/ZnO NPs) with varying degrees of coating. Diverse studies were performed to analyze the toxicity of NPs against cells in a dose-and time-dependent manner. To ensure the decreased toxicity of the produced SiO2/ZnO NPs, cytotoxicity in membrane damage and/or intracellular reactive oxygen species (ROS) were assessed by employing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, lactate dehydrogenase, 2',7'-dichlorofluorescin, and lipid peroxide estimations. The cores of ZnO NPs exhibited cytotoxicity over time, regardless of shell thickness. Nevertheless, the thicker SiO2/ZnO NPs revealed reduced enzyme leakage, decreased peroxide production, and less oxidative stress than their bare ZnO NPs or thinner SiO2/ZnO NPs. Therefore, thicker SiO2/ZnO NPs moderated the toxicity of ZnO NPs by restricting free radical formation and the release of zinc ions, and decreasing surface contact with cells. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.subject | SILICA NANOPARTICLES | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | PHOTOTHERMAL THERAPY | - |
dc.subject | CELLULAR-RESPONSES | - |
dc.subject | LIPID-PEROXIDATION | - |
dc.subject | ZNO NANOPARTICLES | - |
dc.subject | EPITHELIAL-CELLS | - |
dc.subject | GOLD NANORODS | - |
dc.subject | CYTOTOXICITY | - |
dc.subject | NANOSTRUCTURES | - |
dc.title | Role of surface modification in zinc oxide nanoparticles and its toxicity assessment toward human dermal fibroblast cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000340169100001 | - |
dc.identifier.doi | 10.2147/IJN.S65086 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NANOMEDICINE, v.9, pp.3707 - 3718 | - |
dc.identifier.scopusid | 2-s2.0-84905842852 | - |
dc.citation.endPage | 3718 | - |
dc.citation.startPage | 3707 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Ramasamy, Mohankandhasamy | - |
dc.contributor.affiliatedAuthor | Das, Minakshi | - |
dc.contributor.affiliatedAuthor | An, Seong Soo A. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | zinc oxide | - |
dc.subject.keywordAuthor | silica coating | - |
dc.subject.keywordAuthor | photostability | - |
dc.subject.keywordAuthor | human dermal fibroblast | - |
dc.subject.keywordAuthor | membrane damage | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordPlus | SILICA NANOPARTICLES | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | PHOTOTHERMAL THERAPY | - |
dc.subject.keywordPlus | CELLULAR-RESPONSES | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | ZNO NANOPARTICLES | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | GOLD NANORODS | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
dc.subject.keywordPlus | NANOSTRUCTURES | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.