Spatially defined hydrophobic coating of a microwell-patterned hydrophilic polymer substrate for targeted adhesion with high-resolution soft lithography
- Authors
- Lee, Nae Yoon
- Issue Date
- 1-Nov-2013
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Wettability tuning; Selective hydrophobization; Poly(dimethylsiloxane) (PDMS) contact printing; UV curing; Targeted adhesion; Soft lithography
- Citation
- COLLOIDS AND SURFACES B-BIOINTERFACES, v.111, pp.313 - 320
- Journal Title
- COLLOIDS AND SURFACES B-BIOINTERFACES
- Volume
- 111
- Start Page
- 313
- End Page
- 320
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14127
- DOI
- 10.1016/j.colsurfb.2013.06.027
- ISSN
- 0927-7765
- Abstract
- In this study, a simple and facile scheme for selectively hydrophobizing microwell-patterned hydrophilic polymer substrate is demonstrated, and applied for a targeted adhesion. Microwell-patterned polymer substrate was replicated from a silicon mold using a photocurable prepolymer under ultraviolet (UV) light for 30 min. While the surface of the replica was partially cured, it was contact printed with a flat, hydrophobic poly(dimethylsiloxane) (PDMS) elastomer, and the assembly was further cured under UV light for approximately 3 h and detached. In this manner, the PDMS molecules were transferred selectively onto the protruding regions of the partially cured microwell-patterned substrate, while the inner walls of the microwells remained hydrophilic. The surface hydrophobization was characterized by contact angle measurement and X-ray photoelectron spectroscopy (XPS). In addition, time-dependent contact angle variations were investigated to verify the robustness and durability of the coating of the PDMS functional group. As a proof-of-concept experiment, functionalized polymer beads were targeted and successfully guided selectively into arrays of microwells without being adsorbed onto the protruding regions of the microwell-patterned substrate, which could further be applied for the targeted immobilization of biomolecules with high selectivity in a relatively simple and facile manner. (C) 2013 Elsevier B.V. All rights reserved.
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