Glycol chitosan-coated near-infrared photosensitizer-encapsulated gold nanocages for glioblastoma phototherapy
DC Field | Value | Language |
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dc.contributor.author | Battogtokh, Gantumur | - |
dc.contributor.author | Gotov, Oyuntuya | - |
dc.contributor.author | Kang, Ji Hee | - |
dc.contributor.author | Hong, Eun Ji | - |
dc.contributor.author | Shim, Min Suk | - |
dc.contributor.author | Shin, Dongyun | - |
dc.contributor.author | Ko, Young Tag | - |
dc.date.available | 2020-02-27T02:42:58Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-06 | - |
dc.identifier.issn | 1549-9634 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1421 | - |
dc.description.abstract | Photodynamic therapy is a clinically approved treatment approach for cancer. However, it has limited applications owing to poor water solubility and the short wavelength absorption of the photosensitizer (PS). We selected a near-infrared photosensitizer, SiNC, and encapsulated into a gold nanocage (AuNC) in the presence of phase-changing material. Then, the PS-encapsulated nanocage was coated with glycol chitosan (GC) with a cleavable peptide linkage or stable cysteine linkage to protect the PS from premature release and to improve the biocompatibility of the nanocage. We obtained particles of GC-coated SiNC-encapsulated AuNC with a neutral surface charge and approximately 160 nm in size. The enzyme-cleavable peptide-linked GC formulation (GC-pep@SiNC-AuNC) showed stronger phototoxicity and tumor suppression efficacy in a glioblastoma model compared with free NIR-PS and stable cysteine-linked GC-AuNC (GC-cys@SiNC-AuNC). This polymer-coated SiNC-AuNC may be a promising agent for brain cancer phototherapy. (C) 2018 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | - |
dc.subject | PHOTODYNAMIC THERAPY PDT | - |
dc.subject | CONTROLLED-RELEASE | - |
dc.subject | CANCER | - |
dc.subject | NANOPARTICLES | - |
dc.subject | MECHANISMS | - |
dc.subject | STABILITY | - |
dc.subject | POLYMERS | - |
dc.subject | AGENT | - |
dc.subject | OXIDE | - |
dc.title | Glycol chitosan-coated near-infrared photosensitizer-encapsulated gold nanocages for glioblastoma phototherapy | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000471900300028 | - |
dc.identifier.doi | 10.1016/j.nano.2018.10.007 | - |
dc.identifier.bibliographicCitation | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, v.18, pp.315 - 325 | - |
dc.identifier.scopusid | 2-s2.0-85056729523 | - |
dc.citation.endPage | 325 | - |
dc.citation.startPage | 315 | - |
dc.citation.title | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | - |
dc.citation.volume | 18 | - |
dc.contributor.affiliatedAuthor | Gotov, Oyuntuya | - |
dc.contributor.affiliatedAuthor | Kang, Ji Hee | - |
dc.contributor.affiliatedAuthor | Shin, Dongyun | - |
dc.contributor.affiliatedAuthor | Ko, Young Tag | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Glycol chitosan coating | - |
dc.subject.keywordAuthor | Gold nanocage | - |
dc.subject.keywordAuthor | Phototherapy | - |
dc.subject.keywordAuthor | Near-infrared photosensitizer | - |
dc.subject.keywordAuthor | Bioluminescence intensity (BLI) | - |
dc.subject.keywordPlus | PHOTODYNAMIC THERAPY PDT | - |
dc.subject.keywordPlus | CONTROLLED-RELEASE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | POLYMERS | - |
dc.subject.keywordPlus | AGENT | - |
dc.subject.keywordPlus | OXIDE | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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