Glycol chitosan-coated near-infrared photosensitizer-encapsulated gold nanocages for glioblastoma phototherapy
- Authors
- Battogtokh, Gantumur; Gotov, Oyuntuya; Kang, Ji Hee; Hong, Eun Ji; Shim, Min Suk; Shin, Dongyun; Ko, Young Tag
- Issue Date
- Jun-2019
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Glycol chitosan coating; Gold nanocage; Phototherapy; Near-infrared photosensitizer; Bioluminescence intensity (BLI)
- Citation
- NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, v.18, pp.315 - 325
- Journal Title
- NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
- Volume
- 18
- Start Page
- 315
- End Page
- 325
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1421
- DOI
- 10.1016/j.nano.2018.10.007
- ISSN
- 1549-9634
- Abstract
- Photodynamic therapy is a clinically approved treatment approach for cancer. However, it has limited applications owing to poor water solubility and the short wavelength absorption of the photosensitizer (PS). We selected a near-infrared photosensitizer, SiNC, and encapsulated into a gold nanocage (AuNC) in the presence of phase-changing material. Then, the PS-encapsulated nanocage was coated with glycol chitosan (GC) with a cleavable peptide linkage or stable cysteine linkage to protect the PS from premature release and to improve the biocompatibility of the nanocage. We obtained particles of GC-coated SiNC-encapsulated AuNC with a neutral surface charge and approximately 160 nm in size. The enzyme-cleavable peptide-linked GC formulation (GC-pep@SiNC-AuNC) showed stronger phototoxicity and tumor suppression efficacy in a glioblastoma model compared with free NIR-PS and stable cysteine-linked GC-AuNC (GC-cys@SiNC-AuNC). This polymer-coated SiNC-AuNC may be a promising agent for brain cancer phototherapy. (C) 2018 Elsevier Inc. All rights reserved.
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