Relationship of oestrogen receptor status to depressive symptoms and quality of life in breast cancer patients
DC Field | Value | Language |
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dc.contributor.author | Kim, Jong-Hoon | - |
dc.contributor.author | Lee, Byoung-Jo | - |
dc.contributor.author | Bae, Jae-Nam | - |
dc.contributor.author | Hahm, Bong-Jin | - |
dc.date.available | 2020-02-28T22:45:55Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-10 | - |
dc.identifier.issn | 1601-5215 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14255 | - |
dc.description.abstract | Objective We investigated the relationship of oestrogen receptor (ER) status to the severity of depressive symptoms and quality of life (QOL) impairment in breast cancer patients. Methods Seventy-seven breast cancer patients with comorbid depression were evaluated with the Hamilton Depression Rating Scale (HAMD), the Clinical Global Impression-Severity of Illness (CGI-S) for depression, and the Functional Assessment of Cancer Therapy-Breast (FACT-B). ER status was determined using immunohistochemical analysis. Results The ER-positive group (n = 31) showed significantly higher scores compared with the ER-negative group (n = 46) on HAMD total (p = 0.04) and somatic anxiety factor (p = 0.004) scores as well as CGI-S score (p = 0.03). As for QOL measured with the FACT-B, a significantly higher score was found on the Functional Well-Being (FWB) subscale in the ER-positive group (p = 0.001). The relationships were further analysed using generalised linear models (GLM), after controlling for the influence of the current anti-oestrogen treatment. The analysis revealed that ER status was still significantly related to the FWB subscale score of the FACT-B (p = 0.04). However, the HAMD and CGI-S scores were no longer significantly related to ER status after the influence of anti-oestrogen treatment was controlled for. Conclusion These results suggest that ER status, which is a well-known biological prognostic factor in breast cancer, may be related to the severity of certain aspects of depressive symptoms or QOL impairment, implying a role of the ER in affective and behavioural regulation. However, anti-oestrogen treatments significantly influence these relationships. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | CAMBRIDGE UNIV PRESS | - |
dc.relation.isPartOf | ACTA NEUROPSYCHIATRICA | - |
dc.subject | PROGESTERONE-RECEPTORS | - |
dc.subject | RATING-SCALE | - |
dc.subject | WOMEN | - |
dc.subject | TAMOXIFEN | - |
dc.subject | EFFICACY | - |
dc.subject | MANIA | - |
dc.title | Relationship of oestrogen receptor status to depressive symptoms and quality of life in breast cancer patients | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000330359700005 | - |
dc.identifier.doi | 10.1017/neu.2013.5 | - |
dc.identifier.bibliographicCitation | ACTA NEUROPSYCHIATRICA, v.25, no.5, pp.283 - 288 | - |
dc.identifier.scopusid | 2-s2.0-84884765147 | - |
dc.citation.endPage | 288 | - |
dc.citation.startPage | 283 | - |
dc.citation.title | ACTA NEUROPSYCHIATRICA | - |
dc.citation.volume | 25 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Kim, Jong-Hoon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | anti-oestrogen treatment | - |
dc.subject.keywordAuthor | breast cancer | - |
dc.subject.keywordAuthor | depressive symptoms | - |
dc.subject.keywordAuthor | oestrogen receptor status | - |
dc.subject.keywordAuthor | QOL | - |
dc.subject.keywordPlus | PROGESTERONE-RECEPTORS | - |
dc.subject.keywordPlus | RATING-SCALE | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | TAMOXIFEN | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | MANIA | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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