Relationship of oestrogen receptor status to depressive symptoms and quality of life in breast cancer patients
- Authors
- Kim, Jong-Hoon; Lee, Byoung-Jo; Bae, Jae-Nam; Hahm, Bong-Jin
- Issue Date
- Oct-2013
- Publisher
- CAMBRIDGE UNIV PRESS
- Keywords
- anti-oestrogen treatment; breast cancer; depressive symptoms; oestrogen receptor status; QOL
- Citation
- ACTA NEUROPSYCHIATRICA, v.25, no.5, pp.283 - 288
- Journal Title
- ACTA NEUROPSYCHIATRICA
- Volume
- 25
- Number
- 5
- Start Page
- 283
- End Page
- 288
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14255
- DOI
- 10.1017/neu.2013.5
- ISSN
- 1601-5215
- Abstract
- Objective We investigated the relationship of oestrogen receptor (ER) status to the severity of depressive symptoms and quality of life (QOL) impairment in breast cancer patients. Methods Seventy-seven breast cancer patients with comorbid depression were evaluated with the Hamilton Depression Rating Scale (HAMD), the Clinical Global Impression-Severity of Illness (CGI-S) for depression, and the Functional Assessment of Cancer Therapy-Breast (FACT-B). ER status was determined using immunohistochemical analysis. Results The ER-positive group (n = 31) showed significantly higher scores compared with the ER-negative group (n = 46) on HAMD total (p = 0.04) and somatic anxiety factor (p = 0.004) scores as well as CGI-S score (p = 0.03). As for QOL measured with the FACT-B, a significantly higher score was found on the Functional Well-Being (FWB) subscale in the ER-positive group (p = 0.001). The relationships were further analysed using generalised linear models (GLM), after controlling for the influence of the current anti-oestrogen treatment. The analysis revealed that ER status was still significantly related to the FWB subscale score of the FACT-B (p = 0.04). However, the HAMD and CGI-S scores were no longer significantly related to ER status after the influence of anti-oestrogen treatment was controlled for. Conclusion These results suggest that ER status, which is a well-known biological prognostic factor in breast cancer, may be related to the severity of certain aspects of depressive symptoms or QOL impairment, implying a role of the ER in affective and behavioural regulation. However, anti-oestrogen treatments significantly influence these relationships.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14255)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.