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Cited 82 time in webofscience Cited 91 time in scopus
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Targeting the Transforming Growth Factor-beta Signaling in Cancer Therapy

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dc.contributor.authorSheen, Yhun Yhong-
dc.contributor.authorKim, Min-Jin-
dc.contributor.authorPark, Sang-A-
dc.contributor.authorPark, So-Yeon-
dc.contributor.authorNam, Jeong-Seok-
dc.date.available2020-02-28T22:46:47Z-
dc.date.created2020-02-06-
dc.date.issued2013-09-30-
dc.identifier.issn1976-9148-
dc.identifier.urihttps://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14294-
dc.description.abstractTGF-beta pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-beta (TGF-beta) signaling pathway has the dual role in both tumor suppression and tumor promotion. To design cancer therapeutics successfully, it is important to understand TGF-beta related functional contexts. This review discusses the molecular mechanism of the TGF-beta pathway and describes the different ways of tumor suppression and promotion by TGF-beta. In the last part of the review, the data on targeting TGF-beta pathway for cancer treatment is assessed. The TGF-beta inhibitors in pre-clinical studies, and Phase I and II clinical trials are updated.-
dc.language영어-
dc.language.isoen-
dc.publisherKOREAN SOC APPLIED PHARMACOLOGY-
dc.relation.isPartOfBIOMOLECULES & THERAPEUTICS-
dc.subjectEPITHELIAL-MESENCHYMAL TRANSITION-
dc.subjectII RECEPTOR GENE-
dc.subjectTGF-BETA-
dc.subjectKINASE INHIBITOR-
dc.subjectCARCINOMA CELLS-
dc.subjectBONE METASTASIS-
dc.subjectIN-VITRO-
dc.subjectMUTATIONS-
dc.subjectANTAGONIST-
dc.subjectEXPRESSION-
dc.titleTargeting the Transforming Growth Factor-beta Signaling in Cancer Therapy-
dc.typeArticle-
dc.type.rimsART-
dc.description.journalClass1-
dc.identifier.wosid000329335600001-
dc.identifier.doi10.4062/biomolther.2013.072-
dc.identifier.bibliographicCitationBIOMOLECULES & THERAPEUTICS, v.21, no.5, pp.323 - 331-
dc.identifier.kciidART001808411-
dc.identifier.scopusid2-s2.0-84885063519-
dc.citation.endPage331-
dc.citation.startPage323-
dc.citation.titleBIOMOLECULES & THERAPEUTICS-
dc.citation.volume21-
dc.citation.number5-
dc.contributor.affiliatedAuthorNam, Jeong-Seok-
dc.type.docTypeReview-
dc.subject.keywordAuthorTransforming growth factor-beta (TGF-beta)-
dc.subject.keywordAuthorEW-7197-
dc.subject.keywordAuthorALK5-
dc.subject.keywordAuthorBreast cancer-
dc.subject.keywordAuthorMetastasis-
dc.subject.keywordPlusEPITHELIAL-MESENCHYMAL TRANSITION-
dc.subject.keywordPlusII RECEPTOR GENE-
dc.subject.keywordPlusTGF-BETA-
dc.subject.keywordPlusKINASE INHIBITOR-
dc.subject.keywordPlusCARCINOMA CELLS-
dc.subject.keywordPlusBONE METASTASIS-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusMUTATIONS-
dc.subject.keywordPlusANTAGONIST-
dc.subject.keywordPlusEXPRESSION-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
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