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Targeting the Transforming Growth Factor-beta Signaling in Cancer Therapy
- Issue Date
- 30-Sep-2013
- Publisher
- KOREAN SOC APPLIED PHARMACOLOGY
- Keywords
- Transforming growth factor-beta (TGF-beta); EW-7197; ALK5; Breast cancer; Metastasis
- Citation
- BIOMOLECULES & THERAPEUTICS, v.21, no.5, pp.323 - 331
- Journal Title
- BIOMOLECULES & THERAPEUTICS
- Volume
- 21
- Number
- 5
- Start Page
- 323
- End Page
- 331
- ISSN
- 1976-9148
- Abstract
- TGF-beta pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-beta (TGF-beta) signaling pathway has the dual role in both tumor suppression and tumor promotion. To design cancer therapeutics successfully, it is important to understand TGF-beta related functional contexts. This review discusses the molecular mechanism of the TGF-beta pathway and describes the different ways of tumor suppression and promotion by TGF-beta. In the last part of the review, the data on targeting TGF-beta pathway for cancer treatment is assessed. The TGF-beta inhibitors in pre-clinical studies, and Phase I and II clinical trials are updated.
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