Inhibitory effect of Coptis chinensis on inflammation in LPS-induced endotoxemia
- Authors
- Choi, You Yeon; Kim, Mi Hye; Cho, Ik-Hyun; Kim, Ji Hee; Hong, Jongki; Lee, Tae Hee; Yang, Woong Mo
- Issue Date
- Sep-2013
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Coptis chinensis; Lipopolysaccharide (LPS); IL-6; NF-kappa B; MAPKs
- Citation
- JOURNAL OF ETHNOPHARMACOLOGY, v.149, no.2, pp.506 - 512
- Journal Title
- JOURNAL OF ETHNOPHARMACOLOGY
- Volume
- 149
- Number
- 2
- Start Page
- 506
- End Page
- 512
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14339
- DOI
- 10.1016/j.jep.2013.07.008
- ISSN
- 0378-8741
- Abstract
- Ethnopharmacological relevance: Rhizoma coptidis (RC) has been used as a remedy for inflammation-related diseases in traditional medicine. Although it is known to have anti-inflammatory activities, its mechanism of action on lipopolysaccharide (LPS)-induced inflammation has not yet been identified in detail. Aim of the study: This study was designed to assess the beneficial effects of pretreatment with RC in ameliorating LPS-induced liver inflammation. Materials and methods: Mice were orally administered RC (500, 1000 mg/kg) for three days in a row. 1 h after the last RC administration, the mice were intraperitoneally injected with LPS (35 mg/kg). After treatment, histological alterations and inflammatory factor levels in the liver and proinflammatory cytokines in the serum associated with inflammation were examined. Results: We found that pretreatment with RC (500 and 1000 mg/kg) exerted a significant protective effect by attenuating liver histopathological changes in endotoxemic mice. The results also demonstrated that RC suppressed secretion of LPS-stimulated pro-inflammatory cytokines, such as interleukin-6 (IL-6). Furthermore, RC inhibited LPS-mediated nuclear factor (NF)-kappa B activation via the prevention of I kappa B-alpha phosphorylation, as well as the phosphorylation of ERK1/2, JNK, and p38 MAPKs. These results were associated with decreases in the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (I-NOS). Conclusions: The results presented here dearly demonstrate that RC could significantly protect mice against LPS-induced acute liver injury. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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