Prognostic imaging of iatrogenic and traumatic ureteral injury by near-infrared fluorescence
- Authors
- Ahn, Chi Bum; Kim, Joo Hyun; Park, G. Kate; Park, Kook Yang; Bao, Kai; Lee, Jin Woo; Choi, Hak Soo; Son, Kuk Hui
- Issue Date
- Jun-2019
- Publisher
- AME PUBL CO
- Keywords
- Ureteral injury; real-time imaging; zwitterionic fluorophore; disease prognosis
- Citation
- QUANTITATIVE IMAGING IN MEDICINE AND SURGERY, v.9, no.6, pp.1056 - 1065
- Journal Title
- QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
- Volume
- 9
- Number
- 6
- Start Page
- 1056
- End Page
- 1065
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1436
- DOI
- 10.21037/qims.2019.06.15
- ISSN
- 2223-4292
- Abstract
- Background: latrogenic or traumatic ureteral injuries are life-threatening but difficult to diagnose early. Ureteral visualization is essential for both the prevention and diagnosis of iatrogenic or traumatic ureter injuries. In the present study, we evaluated the feasibility of near-infrared (NIR) with ZW800-1C as a diagnostic tool of iatrogenic or traumatic ureteral injury in addition to ureter visualization, compared to methylene blue. Methods: With mice model, we compared the image quality of ZW800-1C with methylene blue for ureter visualization. We also made ureter perforation, obstruction, crushing injury, and transection model with mice and evaluated the feasibility of ZW800-1C for diagnostic tool for ureteral injuries. Results: We could confirm the ureter in the ZW800-1C images in maximally 30 minutes after injection, and the ureter was visible until NIR imaging concluded at 180 minutes after injection. However, methylene blue failed to provide clear ureter imaging during the same period. ZW800-1C imaging successfully visualized ureters subjected to obstruction, transection, perforation, and crush injuries, although urinary leakage was not visible by eye. Conclusions: Our results indicate ZW800-1C is better suited for ureter visualization than methylene blue and that ZW800-1C has considerable potential for the early diagnosis of various ureteral injuries.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의예과 > 1. Journal Articles
- 의과대학 > 의학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1436)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.