Smooth Muscle Relaxation Activity of an Aqueous Extract of Dried Immature Fruit of Poncirus trifoliata (PF-W) on an Isolated Strip of Rat Ileum
- Authors
- Kim, Kyu-Sang; Shim, Won-Sik; dela Pena, Ike Campomayor; Seo, Eun-Kyung; Kim, Woo-Young; Jin, Hyo-Eon; Kim, Dae-Duk; Chung, Suk-Jae; Cheong, Jae-Hoon; Shim, Chang-Koo
- Issue Date
- Aug-2013
- Publisher
- SAGE PUBLICATIONS INC
- Keywords
- Poncirus trifoliata; Water extract; Smooth muscle relaxation; Rat ileum; Gastrointestinal motility
- Citation
- NATURAL PRODUCT COMMUNICATIONS, v.8, no.8, pp.1143 - 1148
- Journal Title
- NATURAL PRODUCT COMMUNICATIONS
- Volume
- 8
- Number
- 8
- Start Page
- 1143
- End Page
- 1148
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14384
- ISSN
- 1934-578X
- Abstract
- We demonstrated that an aqueous extract of dried immature fruit of Poncirus trifoliate (PF-W) produces relaxation of intestinal smooth muscle using the ileac strips of a rat. Furthermore, the underlying mechanism of its relaxant activity was investigated. PF-W was prepared using the standard extraction protocol. A 1.5 - 2 cm long rat ileac strip was placed in an organ bath with Tyrode's solution and smooth muscle contractility was recorded by connecting it to a force transducer. Various compounds were added to the organ baths, and changes in muscular contractility were measured. PF-W concentration-dependently induced relaxation of rat ileac strips that were contracted both spontaneously and via acetylcholine treatment. Various potassium channel blockers did not inhibit the relaxation by PF-W. No difference in the effect of PF-W was observed between ileac strips treated with low (20 mM) and high concentrations (60 mM) of KCl. PF-W inhibited the contraction of rat ileac strips induced by extracellular calcium. PF-W acts as a potent smooth muscle relaxant, implicating its possible action as a rapid acting reliever for abdominal pains and a cure for intestinal convulsion. Considering that PF-W also exhibits prokinetic activity, its use in various gastrointestinal disorders seems promising.
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