Reconstruction of radial bone defect using gelatin sponge and a BMP-2 combination graft
DC Field | Value | Language |
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dc.contributor.author | Kim, Seong-Gon | - |
dc.contributor.author | Jeong, Jae-Hwan | - |
dc.contributor.author | Che, Xiangguo | - |
dc.contributor.author | Park, Yong-Tae | - |
dc.contributor.author | Lee, Sang-Woon | - |
dc.contributor.author | Jung, Eun-Sun | - |
dc.contributor.author | Choe, Senyon | - |
dc.contributor.author | Choi, Je-Yong | - |
dc.date.available | 2020-02-28T23:44:52Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-06-30 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14467 | - |
dc.description.abstract | Many bioactive molecules like recombinant human bone morphogenetic protein 2 (rhBMP-2) have been developed for mineralized bone grafts, for which proper scaffolds are necessary to successfully apply the bioactive molecules. In this study, we tested the osteogenic efficacy of rhBMP-2 produced in-house in combination with gelatin sponge as the scaffold carrier in a rabbit radial defect model. The efficacy of the rhBMP-2 was determined by alkaline phosphatase activity assay of C2C12 cells. Two groups of ten rabbits each were treated with rhBMP-2/gelatin sponge, or gelatin sponge only. At 4 weeks, rhBMP-2/gelatin sponge grafts showed more bone regeneration than gelatin sponge grafts, as determined by X-ray radiography, micro-computed tomography, and histological analyses. At 8 weeks, rhBMP-2/gelatin sponge grafts exerted much stronger osteogenic effects. The study demonstrates the improved osteogenic efficacy of the rhBMP-2/gelatin sponge grafts in a rabbit radial bone defect model acting as a bone-inductive material. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.subject | MORPHOGENETIC PROTEIN-2 | - |
dc.subject | TRICALCIUM PHOSPHATE | - |
dc.subject | CONTROLLED-RELEASE | - |
dc.subject | HYDROXYAPATITE | - |
dc.subject | DELIVERY | - |
dc.subject | HEPARIN | - |
dc.subject | REGENERATION | - |
dc.subject | HYDROGELS | - |
dc.subject | MATRIX | - |
dc.subject | MODEL | - |
dc.title | Reconstruction of radial bone defect using gelatin sponge and a BMP-2 combination graft | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000324920700007 | - |
dc.identifier.doi | 10.5483/BMBRep.2013.46.6.231 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.46, no.6, pp.328 - 333 | - |
dc.identifier.kciid | ART001776474 | - |
dc.identifier.scopusid | 2-s2.0-84880583924 | - |
dc.citation.endPage | 333 | - |
dc.citation.startPage | 328 | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 46 | - |
dc.citation.number | 6 | - |
dc.contributor.affiliatedAuthor | Choe, Senyon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | BMP-2 | - |
dc.subject.keywordAuthor | Bone defect | - |
dc.subject.keywordAuthor | Bone graft | - |
dc.subject.keywordAuthor | Gelatin sponge | - |
dc.subject.keywordAuthor | Osteogenic activity | - |
dc.subject.keywordPlus | MORPHOGENETIC PROTEIN-2 | - |
dc.subject.keywordPlus | TRICALCIUM PHOSPHATE | - |
dc.subject.keywordPlus | CONTROLLED-RELEASE | - |
dc.subject.keywordPlus | HYDROXYAPATITE | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | HEPARIN | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | HYDROGELS | - |
dc.subject.keywordPlus | MATRIX | - |
dc.subject.keywordPlus | MODEL | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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