Reconstruction of radial bone defect using gelatin sponge and a BMP-2 combination graft
- Authors
- Kim, Seong-Gon; Jeong, Jae-Hwan; Che, Xiangguo; Park, Yong-Tae; Lee, Sang-Woon; Jung, Eun-Sun; Choe, Senyon; Choi, Je-Yong
- Issue Date
- 30-Jun-2013
- Publisher
- KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- Keywords
- BMP-2; Bone defect; Bone graft; Gelatin sponge; Osteogenic activity
- Citation
- BMB REPORTS, v.46, no.6, pp.328 - 333
- Journal Title
- BMB REPORTS
- Volume
- 46
- Number
- 6
- Start Page
- 328
- End Page
- 333
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14467
- DOI
- 10.5483/BMBRep.2013.46.6.231
- ISSN
- 1976-6696
- Abstract
- Many bioactive molecules like recombinant human bone morphogenetic protein 2 (rhBMP-2) have been developed for mineralized bone grafts, for which proper scaffolds are necessary to successfully apply the bioactive molecules. In this study, we tested the osteogenic efficacy of rhBMP-2 produced in-house in combination with gelatin sponge as the scaffold carrier in a rabbit radial defect model. The efficacy of the rhBMP-2 was determined by alkaline phosphatase activity assay of C2C12 cells. Two groups of ten rabbits each were treated with rhBMP-2/gelatin sponge, or gelatin sponge only. At 4 weeks, rhBMP-2/gelatin sponge grafts showed more bone regeneration than gelatin sponge grafts, as determined by X-ray radiography, micro-computed tomography, and histological analyses. At 8 weeks, rhBMP-2/gelatin sponge grafts exerted much stronger osteogenic effects. The study demonstrates the improved osteogenic efficacy of the rhBMP-2/gelatin sponge grafts in a rabbit radial bone defect model acting as a bone-inductive material.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14467)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.