A study of Gd loaded silica nanoparticles for both optical and magnetic resonance imaging of cells
- Authors
- Lee, Haisung; Yi, Dong Kee
- Issue Date
- 1-Jun-2013
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Gd ion; Dual imaging; Colloid; MRI agent; Hybrid
- Citation
- MATERIALS LETTERS, v.100, pp.98 - 101
- Journal Title
- MATERIALS LETTERS
- Volume
- 100
- Start Page
- 98
- End Page
- 101
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14487
- DOI
- 10.1016/j.matlet.2013.03.016
- ISSN
- 0167-577X
- Abstract
- We have developed fluorescent nanoparticle-based T-1 contrast enhancing magnetic resonance imaging (MRI) agents, for the purpose of dual imaging in vivo. Gd(III) chelated silica nanoparticles were successfully synthesized with dual-mode diagnostics feasibility in MRI and fluorescence imaging analysis. Gd-chelated silica nanoparticles were studied, which were formed via polyelectrolyte encapping methods. A 9.4T micro-image instrument was used to investigate the T-1 contrast enhancement effects of the Gd-chelated silica nanoparticles. The resulting Gd chelated nanoparticles were used in cell tracking and bio-distribution experiments with dual mode imaging of A549 lung cancer cells and mouse models. These Gd-silica nanoparticles are promising dual mode materials, functioning as T-1 MRI contrast agents and organ specific contrast agents. (C) 2013 Elsevier B.V. All rights reserved.
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