Origin of B-0 orientation dependent R*(2) (=1/T*(2)) in white matter
- Authors
- Oh, Se-Hong; Kim, Young-Bo; Cho, Zang-Hee; Lee, Jongho
- Issue Date
- Jun-2013
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Magnetic susceptibility anisotropy; Magic angle effects; B-0 orientation dependent transverse magnetization (T-2 and T*(2)); MRI relaxometry
- Citation
- NEUROIMAGE, v.73, pp.71 - 79
- Journal Title
- NEUROIMAGE
- Volume
- 73
- Start Page
- 71
- End Page
- 79
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14489
- DOI
- 10.1016/j.neuroimage.2013.01.051
- ISSN
- 1053-8119
- Abstract
- Recent MRI studies have demonstrated that the relative orientation of white matter fibers to the B-0 field significantly affects R*(2) measurement. In this work, the origin of this effect was investigated by measuring R-2 and R*(2) in multiple orientations and fitting the results to magnetic susceptibility-based models and magic angle-based models. To further explore the source of magnetic susceptibility effect, the contribution of tissue iron to the orientation dependent R*(2) contrast was investigated. Additionally, the effects of temperature on R*(2) and orientation dependent R*(2) contrasts were studied to understand the differences reported between a fixed specimen at room temperature and in vivo at body temperature. The results suggest that the B-0 dependent R*(2) variation is better explained by the magnetic susceptibility-based model with susceptibility anisotropy. However, extracting tissue iron did not reduce the orientation dependent R*(2) contrast, suggesting iron is not the origin of the contrast. This leaves susceptibility effects from myelin as the most probable origin of the contrast. Temperature showed large contribution on both R*(2) and orientation dependent R*(2) contrasts, explaining a portion of the contrast difference between the in-vivo and in-vitro conditions. (C) 2013 Elsevier Inc. All rights reserved.
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