Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma
- Authors
- Ha, Seung Yeon; Ahn, Jungsuk; Roh, Mee Sook; Han, Joungho; Lee, Jae Jun; Lee, Boin; Yim, Jun
- Issue Date
- Jun-2013
- Publisher
- KOREAN SOCIETY PATHOLOGISTS
- Keywords
- Adenocarcinoma; Lung; Anaplastic lymphoma kinase; Carcinoma, non-small-cell lung; Cytology
- Citation
- KOREAN JOURNAL OF PATHOLOGY, v.47, no.3, pp.252 - 257
- Journal Title
- KOREAN JOURNAL OF PATHOLOGY
- Volume
- 47
- Number
- 3
- Start Page
- 252
- End Page
- 257
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14519
- DOI
- 10.4132/KoreanJPathol.2013.47.3.252
- ISSN
- 1738-1843
- Abstract
- Background: The aim of this study was to determine the cytologic features of anaplastic lymphoma kinase (ALK) expressing pulmonary adenocarcinoma. Methods: We analyzed the cytopathological findings of 15 cases of endobronchial ultrasound guided aspiration and a case of bronchial washing. These cases were selected based on the histomorphology of ALK-rearranged lung adenocarcinoma. Results: Cytology showed mucinous (81.3%) and hemorrhagic (50%) backgrounds. The cells were arranged in tubulopapillary or tubulocribriform patterns (93.8%), and clusters (56.3%) admixed with signet ring cell features (87.5%). The tumor cells were monotonous and uniform with vesicular nuclei and a small nucleolus. Conclusions: The characteristic. findings were sheets showing a tubulopapillary or tubulocribriform appearance, with vesicular nuclei and a bland chromatin pattern (p<0.001). Scattered signet ring cells were helpful in suggesting ALK-positive adenocarcinoma (p<0.001).
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의예과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14519)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.