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Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part II
- Authors
- Yang, Jee Sun; Song, Doona; Ko, Won Jin; Kim, Bunyea; Kim, Bo-Kyung; Park, Song-Kyu; Won, Misun; Lee, Kiho; Lee, Kyeong; Kim, Hwan Mook; Han, Gyoonhee
- Issue Date
- May-2013
- Publisher
- ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
- Keywords
- Aliphatic amido-quaternary ammonium salts; Open-ring form of aliphatic amido-quaternary ammonium salts; RhoB; GTPase RAt Sarcoma (Ras); Perifosine; NSC126188
- Citation
- EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.63, pp.621 - 628
- Journal Title
- EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Volume
- 63
- Start Page
- 621
- End Page
- 628
- ISSN
- 0223-5234
- Abstract
- A series of novel aliphatic amido-quaternary ammonium salts were synthesized and evaluated for their anticancer effects involving induction of RhoB. Most of these compounds, featuring open-ring forms of aliphatic amido-quaternary ammonium salts, exhibited potent anti-proliferative activities in human cancer cell lines, including PC-3, NUGC-3, MDA-MB-231, ACHN, HCT-15, and NCI-H23. In further evaluation, the representative compound N,N-diethyl-N-(2-(N-methyltetradecanamido)ethyl)prop-2-en-1-aminium bromide (3b) exhibited potent pro-apoptotic activity, through RhoB activation, in HeLa cells. (C) 2013 Elsevier Masson SAS. All rights reserved.
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Related Researcher
- Kim, Hwan Mook
- Pharmacy (Dept.of Pharmacy)