Avenanthramide C from germinated oats exhibits anti-allergic inflammatory effects in mast cells
DC Field | Value | Language |
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dc.contributor.author | Dhakal, Hima | - |
dc.contributor.author | Yang, Eun-Ju | - |
dc.contributor.author | Lee, Soyoung | - |
dc.contributor.author | Kim, Min-Jong | - |
dc.contributor.author | Baek, Moon-Chang | - |
dc.contributor.author | Lee, Byungheon | - |
dc.contributor.author | Park, Pil-Hoon | - |
dc.contributor.author | Kwon, Taeg Kyu | - |
dc.contributor.author | Khang, Dongwoo | - |
dc.contributor.author | Song, Kyung-Sik | - |
dc.contributor.author | Kim, Sang-Hyun | - |
dc.date.available | 2020-02-27T03:41:00Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-05-03 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1470 | - |
dc.description.abstract | Mast cells play a crucial role in allergic diseases via the release of inflammatory mediators, particularly histamine and pro-inflammatory cytokines. Avenanthramide (Avn) C, a polyphenol found mainly in oats, is known to exhibit various biological properties. In this study, we aimed to evaluate the effectiveness of Avn C from germinated oats against mast cell-mediated allergic inflammation. For the in vitro study, RBL-2H3, mouse bone marrow-derived mast cells and rat peritoneal mast cells were used. Avn C (1-100 nM) inhibited the immunoglobulin (Ig) E-stimulated mast cells degranulation by suppressing phosphorylation of phosphoinositide 3-kinase and phospholipase C gamma 1 and decreasing intracellular calcium levels. It inhibited IgE-stimulated secretion of inflammatory cytokines via suppression of FceRI-mediated signaling proteins Lyn, Syk, Akt, and nuclear factor-kappa B. To verify the effects of Avn C in vivo, ovalbumin-induced active systemic anaphylaxis (ASA) and IgE-mediated passive cutaneous anaphylaxis (PCA) models were used. Oral administration of Avn C dose-dependently attenuated the ASA reactions, as evidenced by the inhibition of hypothermia and reduction of elevated serum histamine, IgE, and interleukin-4 levels. Avn C also inhibited the PCA reactions, such as ear swelling and plasma extravasation. Our results suggested that Avn C from germinated oats might be a possible therapeutic candidate for mast cell-mediated allergic inflammation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | MEDIATED ALLERGIC INFLAMMATION | - |
dc.subject | DEGRANULATION | - |
dc.subject | ACTIVATION | - |
dc.subject | FOOD | - |
dc.subject | ANAPHYLAXIS | - |
dc.subject | INVOLVEMENT | - |
dc.subject | INHIBITION | - |
dc.subject | PATHWAYS | - |
dc.subject | CALCIUM | - |
dc.title | Avenanthramide C from germinated oats exhibits anti-allergic inflammatory effects in mast cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000466701900023 | - |
dc.identifier.doi | 10.1038/s41598-019-43412-2 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.9 | - |
dc.identifier.scopusid | 2-s2.0-85065164947 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Khang, Dongwoo | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | MEDIATED ALLERGIC INFLAMMATION | - |
dc.subject.keywordPlus | DEGRANULATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | FOOD | - |
dc.subject.keywordPlus | ANAPHYLAXIS | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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