A Transdermal Delivery System to Enhance Quercetin Nanoparticle Permeability
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bennet, Devasier | - |
dc.contributor.author | Kim, Sanghyo | - |
dc.date.available | 2020-02-29T00:44:24Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2013-02-01 | - |
dc.identifier.issn | 0920-5063 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14754 | - |
dc.description.abstract | Targeting oxidative stress with inhibiting or boosting the endogenous levels of antioxidants potentially has an outstanding effect in the treatment of oxidative-stress-related diseases. The present work demonstrates the synthesis of quercetin nanoemulsion as one of the potential antioxidants for the treatment of oxidative- stress-related diseases. A quercetin nanoemulsion was prepared using poly(lactic-co-glycolic acid) (PLGA), hyaluronic acid (HA) and emulsifier (Tween-20) through a solvent evaporation technique. The efficiency of the nanoemulsion was evaluated with and without chemical permeation enhancer (CPE). The FT-IR result shows no interaction between quercetin and polymer that proves excellent compatibility. The transdermal delivery ability was evaluated using in vitro release and ex vivo permeation analysis. The transdermal drug-release mechanism was studied by the mathematical model and was found to obey a zero-order, diffusion-controlled mechanism. In vitro toxicity and cell behavior, including cell adhesion, proliferation and cell death of quercetin-nanoemulsion-treated L929 cells, were elucidated by the electrical cell-substrate impedance sensing (ECIS) technique. The produced nanoemulsion showed a high encapsulation efficiency, less toxicity, controlled delivery with enhanced transdermal drug permeation and effective scavenging of free radicals. (C) Koninklijke Brill NV, Leiden, 2012 | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.relation.isPartOf | JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | - |
dc.subject | IN-VITRO | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | TOPICAL DELIVERY | - |
dc.subject | SKIN PENETRATION | - |
dc.subject | SUBSTRATE | - |
dc.subject | VIVO | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | WATER | - |
dc.subject | CYTOTOXICITY | - |
dc.subject | FLAVONOIDS | - |
dc.title | A Transdermal Delivery System to Enhance Quercetin Nanoparticle Permeability | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000322305000006 | - |
dc.identifier.doi | 10.1163/156856212X630258 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, v.24, no.2, pp.185 - 209 | - |
dc.identifier.scopusid | 2-s2.0-84875337834 | - |
dc.citation.endPage | 209 | - |
dc.citation.startPage | 185 | - |
dc.citation.title | JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | - |
dc.citation.volume | 24 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Bennet, Devasier | - |
dc.contributor.affiliatedAuthor | Kim, Sanghyo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Antioxidant | - |
dc.subject.keywordAuthor | electrical cell-substrate impedance sensing (ECIS) | - |
dc.subject.keywordAuthor | nanoemulsion encapsulation | - |
dc.subject.keywordAuthor | hyaluronic acid | - |
dc.subject.keywordAuthor | PLGA | - |
dc.subject.keywordAuthor | permeation enhancement | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | TOPICAL DELIVERY | - |
dc.subject.keywordPlus | SKIN PENETRATION | - |
dc.subject.keywordPlus | SUBSTRATE | - |
dc.subject.keywordPlus | VIVO | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | WATER | - |
dc.subject.keywordPlus | CYTOTOXICITY | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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