A Transdermal Delivery System to Enhance Quercetin Nanoparticle Permeability
- Authors
- Bennet, Devasier; Kim, Sanghyo
- Issue Date
- 1-Feb-2013
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Antioxidant; electrical cell-substrate impedance sensing (ECIS); nanoemulsion encapsulation; hyaluronic acid; PLGA; permeation enhancement; drug delivery
- Citation
- JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, v.24, no.2, pp.185 - 209
- Journal Title
- JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
- Volume
- 24
- Number
- 2
- Start Page
- 185
- End Page
- 209
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14754
- DOI
- 10.1163/156856212X630258
- ISSN
- 0920-5063
- Abstract
- Targeting oxidative stress with inhibiting or boosting the endogenous levels of antioxidants potentially has an outstanding effect in the treatment of oxidative-stress-related diseases. The present work demonstrates the synthesis of quercetin nanoemulsion as one of the potential antioxidants for the treatment of oxidative- stress-related diseases. A quercetin nanoemulsion was prepared using poly(lactic-co-glycolic acid) (PLGA), hyaluronic acid (HA) and emulsifier (Tween-20) through a solvent evaporation technique. The efficiency of the nanoemulsion was evaluated with and without chemical permeation enhancer (CPE). The FT-IR result shows no interaction between quercetin and polymer that proves excellent compatibility. The transdermal delivery ability was evaluated using in vitro release and ex vivo permeation analysis. The transdermal drug-release mechanism was studied by the mathematical model and was found to obey a zero-order, diffusion-controlled mechanism. In vitro toxicity and cell behavior, including cell adhesion, proliferation and cell death of quercetin-nanoemulsion-treated L929 cells, were elucidated by the electrical cell-substrate impedance sensing (ECIS) technique. The produced nanoemulsion showed a high encapsulation efficiency, less toxicity, controlled delivery with enhanced transdermal drug permeation and effective scavenging of free radicals. (C) Koninklijke Brill NV, Leiden, 2012
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 바이오나노대학 > 바이오나노학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14754)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.