Screening of Chinese herbal medicines with inhibitory effect on Aldose reductase (VII)중국 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색 (VII)
- Other Titles
- 중국 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색 (VII)
- Authors
- Lee, Y.M.; Kim, Y.S.; Kim, J.H.; Kim, J.S.
- Issue Date
- Jun-2013
- Publisher
- 한국생약학회
- Keywords
- Aldose reductase inhibitor; Chinese herbal medicines; Diabetic complications
- Citation
- Korean Journal of Pharmacognosy, v.44, no.2, pp.161 - 167
- Journal Title
- Korean Journal of Pharmacognosy
- Volume
- 44
- Number
- 2
- Start Page
- 161
- End Page
- 167
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14867
- ISSN
- 0253-3073
- Abstract
- Aldose reductase (AR) has been shown to play an important role in the development of the diabetic complications. To discover novel treatments for diabetic complications from natural sources, 59 Chinese herbal medicines have been investigated for inhibitory activities on AR. Among them, 10 herbal medicines, Catalpa fargesii (stem and leaf), Saussurea Laniceps(whole plant), Alnus nepalensis(stem and leaf), Swertia macrosperma (whole plant), Woodfordia fruticosa (stem and leaf), Elsholtzia bodinieri (whole plant), Elsholtzia fruticosa (whole plant), Rosa multiflora (fruit), Nardostachys chinensis (whole plant), Eurya groffii (stem and leaf) exhibited a significant inhibitory activity compared with 3,3-tetramethyleneglutaric acid (TMG) as positive control. Particularly, 4 herbal medicines, C. fargesii (stem and leaf), S. Laniceps (whole plant), A. nepalensis (stem and leaf), S. macrosperma (whole plant) showed two times more potent inhibitory activity than TMG (5.37 μg/ml).
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