Screening of herbal medicines from China with inhibitory activity on advanced glycation end products (AGEs) formation (X)중국 약용식물의 최종당화산물 생성저해활성 검색 (X)
- Other Titles
- 중국 약용식물의 최종당화산물 생성저해활성 검색 (X)
- Authors
- Kim, Y.S.; Lee, Y.M.; Kim, J.H.; Kim, J.S.
- Issue Date
- Sep-2013
- Publisher
- 한국생약학회
- Keywords
- Advanced glycation end products (AGEs); Chinese herbal medicines; Diabetic complications
- Citation
- Korean Journal of Pharmacognosy, v.44, no.3, pp.305 - 311
- Journal Title
- Korean Journal of Pharmacognosy
- Volume
- 44
- Number
- 3
- Start Page
- 305
- End Page
- 311
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14873
- ISSN
- 0253-3073
- Abstract
- Advanced glycation end products (AGEs) have been postulated to play a central role in the development of diabetic complications. A variety of different agents that inhibit AGEs have been under investigation. In this study, 54 herbal medicines from China have been investigated with an in vitro evaluation system using AGEs formation inhibitory activity. Of these, 6 herbal medicines (IC<inf>50</inf><5 μg/ml) were found to have significant AGEs formation inhibitory activity. Particularly, herbal medicines Punica granatum (peels), Terminalia chebula (fruits), Rheum palmatum (roots), Oxyria digyna (stems and leaves), Anisodus luridus (roots) and Quercus schottkyana(stems and leaves) showed more potent inhibitory activity (approximately 9-43 fold) than the positive control aminoguanidine (IC<inf>50</inf>=77.04 μg/ml).
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