Screening of Korean herbal medicines with inhibitory activity on advanced glycation end products formation (IX)한국약용식물의 최종당화산물 생성저해활성 검색 (IX)
- Other Titles
- 한국약용식물의 최종당화산물 생성저해활성 검색 (IX)
- Authors
- Lee, Y.M.; Kim, Y.S.; Kim, J.H.; Kim, J.S.
- Issue Date
- Sep-2013
- Publisher
- 한국생약학회
- Keywords
- Advanced glycation end products (AGEs); Diabetic complications; Korean herbal medicines
- Citation
- Korean Journal of Pharmacognosy, v.44, no.3, pp.298 - 304
- Journal Title
- Korean Journal of Pharmacognosy
- Volume
- 44
- Number
- 3
- Start Page
- 298
- End Page
- 304
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14874
- ISSN
- 0253-3073
- Abstract
- In this study, 64 Korean herbal medicines have been investigated with an in vitro evaluation systems using glycation end products (AGEs) formation inhibitory activity. Of these, 30 herbal medicines (IC<inf>50</inf><50 μg/ml) were found to have significant AGEs formation inhibitory activity. Of these, four herbal medicines (IC<inf>50</inf><5 μg/ml) were found to have significant AGEs formation inhibitory activity. Particularly, Cornus controversa (branches and leaves), Acer ginnala (stems and leaves), Platycarya strobilacea (flowers) and Picrasma quassioides (stems), showed more potent inhibitory activity (approximately 17- 27 fold) than the positive control aminoguanidine (IC<inf>50</inf>=77.04 μg/ml).
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