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Screening of Korean herbal medicines with inhibitory activity on advanced glycation end products formation (IX)한국약용식물의 최종당화산물 생성저해활성 검색 (IX)

Other Titles
한국약용식물의 최종당화산물 생성저해활성 검색 (IX)
Authors
Lee, Y.M.Kim, Y.S.Kim, J.H.Kim, J.S.
Issue Date
Sep-2013
Publisher
한국생약학회
Keywords
Advanced glycation end products (AGEs); Diabetic complications; Korean herbal medicines
Citation
Korean Journal of Pharmacognosy, v.44, no.3, pp.298 - 304
Journal Title
Korean Journal of Pharmacognosy
Volume
44
Number
3
Start Page
298
End Page
304
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/14874
ISSN
0253-3073
Abstract
In this study, 64 Korean herbal medicines have been investigated with an in vitro evaluation systems using glycation end products (AGEs) formation inhibitory activity. Of these, 30 herbal medicines (IC<inf>50</inf><50 μg/ml) were found to have significant AGEs formation inhibitory activity. Of these, four herbal medicines (IC<inf>50</inf><5 μg/ml) were found to have significant AGEs formation inhibitory activity. Particularly, Cornus controversa (branches and leaves), Acer ginnala (stems and leaves), Platycarya strobilacea (flowers) and Picrasma quassioides (stems), showed more potent inhibitory activity (approximately 17- 27 fold) than the positive control aminoguanidine (IC<inf>50</inf>=77.04 μg/ml).
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