RHOA in Gastric Cancer: Functional Roles and Therapeutic Potential
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nam, Seungyoon | - |
dc.contributor.author | Kim, Jung Ho | - |
dc.contributor.author | Lee, Dae Ho | - |
dc.date.available | 2020-02-27T03:41:10Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-05-15 | - |
dc.identifier.issn | 1664-8021 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1491 | - |
dc.description.abstract | The well-known signal mediator and small GTPase family member, RHOA, has now been associated with the progression of specific malignancies. In this review, we appraise the biomedical literature regarding the role of this enzyme in gastric cancer (GC) signaling, suggesting potential clinical significance. To that end, we examined RHOA activity, with regard to second-generation hallmarks of cancer, finding particular association with the hallmark "activation of invasion and metastasis." Moreover, an abundance of studies show RHOA association with Lauren classification diffuse subtype, in addition to poorly differentiated GC. With regard to therapeutic value, we found RHOA signaling to influence the activity of specific widely used chemotherapeutics, and its possible antagonism by various dietary constituents. We also review currently available targeted therapies for GC. The latter, however, showed a paucity of such agents, underscoring the urgent need for further investigation into treatments for this highly lethal malignancy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.relation.isPartOf | FRONTIERS IN GENETICS | - |
dc.subject | HELICOBACTER-PYLORI INFECTION | - |
dc.subject | CELL-MIGRATION | - |
dc.subject | KAPPA-B | - |
dc.subject | CLINICOPATHOLOGICAL CHARACTERISTICS | - |
dc.subject | CHEMOTHERAPY RESISTANCE | - |
dc.subject | INHIBITS MIGRATION | - |
dc.subject | SIGNALING PATHWAY | - |
dc.subject | AGS CELLS | - |
dc.subject | INVASION | - |
dc.subject | ACTIVATION | - |
dc.title | RHOA in Gastric Cancer: Functional Roles and Therapeutic Potential | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000467992000001 | - |
dc.identifier.doi | 10.3389/fgene.2019.00438 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN GENETICS, v.10 | - |
dc.identifier.scopusid | 2-s2.0-85067874280 | - |
dc.citation.title | FRONTIERS IN GENETICS | - |
dc.citation.volume | 10 | - |
dc.contributor.affiliatedAuthor | Nam, Seungyoon | - |
dc.contributor.affiliatedAuthor | Kim, Jung Ho | - |
dc.contributor.affiliatedAuthor | Lee, Dae Ho | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | RHOA | - |
dc.subject.keywordAuthor | gastric cancer | - |
dc.subject.keywordAuthor | stomach cancer | - |
dc.subject.keywordAuthor | therapeutics | - |
dc.subject.keywordAuthor | functions | - |
dc.subject.keywordPlus | HELICOBACTER-PYLORI INFECTION | - |
dc.subject.keywordPlus | CELL-MIGRATION | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | CLINICOPATHOLOGICAL CHARACTERISTICS | - |
dc.subject.keywordPlus | CHEMOTHERAPY RESISTANCE | - |
dc.subject.keywordPlus | INHIBITS MIGRATION | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | AGS CELLS | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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